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dc.contributor.authorHanson, MA
dc.contributor.authorLemaitre, B
dc.date.accessioned2023-08-04T10:47:32Z
dc.date.issued2019-12-11
dc.date.updated2023-08-04T09:39:07Z
dc.description.abstractSince the first animal antimicrobial peptides (AMPs) were discovered in insects, Drosophila melanogaster has emerged as a powerful model for their characterization. Drosophila AMPs have been used extensively to monitor the activity of the Toll and Imd NF-κB pathways, but little was known of their precise functions. In this review, we summarize recent findings on the function of Drosophila AMPs not only for antimicrobial defense, but also in the gut, tumor control, and neurology. The integration of these new studies allows a new framework to be drawn that explains how AMPs can contribute simultaneously to microbe killing whilst also regulating important host cellular functions. These functions require that AMPs target not only negatively charged microbes but also aberrant host cells.en_GB
dc.description.sponsorshipSNF Sinergiaen_GB
dc.description.sponsorshipNovartisen_GB
dc.format.extent22-30
dc.identifier.citationVol. 62, pp. 22-30en_GB
dc.identifier.doihttps://doi.org/10.1016/j.coi.2019.11.008
dc.identifier.grantnumberCRS II5 186397en_GB
dc.identifier.grantnumber532114en_GB
dc.identifier.urihttp://hdl.handle.net/10871/133705
dc.identifierORCID: 0000-0002-6125-3672 (Hanson, Mark Austin)
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/31835066en_GB
dc.rights© 2019 Elsevier Ltd. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/  en_GB
dc.titleNew insights on Drosophila antimicrobial peptide function in host defense and beyonden_GB
dc.typeArticleen_GB
dc.date.available2023-08-04T10:47:32Z
dc.identifier.issn0952-7915
exeter.place-of-publicationEngland
dc.descriptionThis is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record en_GB
dc.identifier.eissn1879-0372
dc.identifier.journalCurrent Opinion in Immunologyen_GB
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/ en_GB
dcterms.dateAccepted2019-11-15
rioxxterms.versionAMen_GB
rioxxterms.licenseref.startdate2019-12-11
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-08-04T10:43:10Z
refterms.versionFCDAM
refterms.dateFOA2023-08-04T10:47:32Z
refterms.panelAen_GB
refterms.dateFirstOnline2019-12-11


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© 2019 Elsevier Ltd. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/  
Except where otherwise noted, this item's licence is described as © 2019 Elsevier Ltd. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/