New insights on Drosophila antimicrobial peptide function in host defense and beyond
dc.contributor.author | Hanson, MA | |
dc.contributor.author | Lemaitre, B | |
dc.date.accessioned | 2023-08-04T10:47:32Z | |
dc.date.issued | 2019-12-11 | |
dc.date.updated | 2023-08-04T09:39:07Z | |
dc.description.abstract | Since the first animal antimicrobial peptides (AMPs) were discovered in insects, Drosophila melanogaster has emerged as a powerful model for their characterization. Drosophila AMPs have been used extensively to monitor the activity of the Toll and Imd NF-κB pathways, but little was known of their precise functions. In this review, we summarize recent findings on the function of Drosophila AMPs not only for antimicrobial defense, but also in the gut, tumor control, and neurology. The integration of these new studies allows a new framework to be drawn that explains how AMPs can contribute simultaneously to microbe killing whilst also regulating important host cellular functions. These functions require that AMPs target not only negatively charged microbes but also aberrant host cells. | en_GB |
dc.description.sponsorship | SNF Sinergia | en_GB |
dc.description.sponsorship | Novartis | en_GB |
dc.format.extent | 22-30 | |
dc.identifier.citation | Vol. 62, pp. 22-30 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.coi.2019.11.008 | |
dc.identifier.grantnumber | CRS II5 186397 | en_GB |
dc.identifier.grantnumber | 532114 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/133705 | |
dc.identifier | ORCID: 0000-0002-6125-3672 (Hanson, Mark Austin) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/31835066 | en_GB |
dc.rights | © 2019 Elsevier Ltd. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.title | New insights on Drosophila antimicrobial peptide function in host defense and beyond | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-08-04T10:47:32Z | |
dc.identifier.issn | 0952-7915 | |
exeter.place-of-publication | England | |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record | en_GB |
dc.identifier.eissn | 1879-0372 | |
dc.identifier.journal | Current Opinion in Immunology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2019-11-15 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2019-12-11 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-08-04T10:43:10Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2023-08-04T10:47:32Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2019-12-11 |
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Except where otherwise noted, this item's licence is described as © 2019 Elsevier Ltd. This version is made available under the CC-BY-NC-ND 4.0 license: https://creativecommons.org/licenses/by-nc-nd/4.0/