Co-ingestion of branched-chain amino acids and carbohydrate stimulates myofibrillar protein synthesis following resistance exercise in trained young men
Jackman, SR; Wallis, GA; Yu, J; et al.Philp, A; Baar, K; Tipton, KD; Witard, OC
Date: 24 May 2023
Article
Journal
International Journal of Sport Nutrition and Exercise Metabolism
Publisher
Human Kinetics
Publisher DOI
Abstract
Branched-chain amino acids (BCAA) and carbohydrate (CHO) are commonly recommended postexercise supplements. However,
no study has examined the interaction of CHO and BCAA ingestion on myofibrillar protein synthesis (MyoPS) rates following
exercise. We aimed to determine the response of MyoPS to the co-ingestion of BCAA and CHO following ...
Branched-chain amino acids (BCAA) and carbohydrate (CHO) are commonly recommended postexercise supplements. However,
no study has examined the interaction of CHO and BCAA ingestion on myofibrillar protein synthesis (MyoPS) rates following
exercise. We aimed to determine the response of MyoPS to the co-ingestion of BCAA and CHO following an acute bout of
resistance exercise. Ten resistance-trained young men completed two trials in counterbalanced order, ingesting isocaloric drinks
containing either 30.6-g CHO plus 5.6-g BCAA (B + C) or 34.7-g CHO alone following a bout of unilateral, leg resistance exercise.
MyoPS was measured postexercise with a primed, constant infusion of L-[ring13
C6] phenylalanine and collection of muscle
biopsies pre- and 4 hr postdrink ingestion. Blood samples were collected at time points before and after drink ingestion. Serum
insulin concentrations increased to a similar extent in both trials (p > .05), peaking at 30 min postdrink ingestion. Plasma leucine
(514 ± 34 nmol/L), isoleucine (282 ± 23 nmol/L), and valine (687 ± 33 nmol/L) concentrations peaked at 0.5 hr postdrink in B + C
and remained elevated for 3 hr during exercise recovery. MyoPS was ∼15% greater (95% confidence interval [−0.002, 0.028],
p = .039, Cohen’s d = 0.63) in B + C (0.128%/hr ± 0.011%/hr) than CHO alone (0.115%/hr ± 0.011%/hr) over the 4 hr postexercise
period. Co-ingestion of BCAA and CHO augments the acute response of MyoPS to resistance exercise in trained young males.
Public Health and Sport Sciences
Faculty of Health and Life Sciences
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