Modelling and experimental investigation of capsule-tumour contact for early bowel cancer detection
dc.contributor.author | Tian, J | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Bi, H | |
dc.contributor.author | Prasad, S | |
dc.contributor.author | Liu, C | |
dc.date.accessioned | 2023-09-25T08:42:09Z | |
dc.date.issued | 2023-09-23 | |
dc.date.updated | 2023-09-24T19:09:15Z | |
dc.description.abstract | Tissue’s mechanical properties, such as stiffness, are critical biomarkers that could be utilised to detect early stages of malignant transformation and distinguish between healthy and abnormal tissues. This paper studied a new method by using a capsule robot to evaluate the stiffness of bowel tumour for early bowel cancer detection and staging. Hertz contact theory was used to model capsule-tumour contact in an intestinal environment. Both lateral and vertical contacts were performed with finite element (FE) and experimental validations. Young’s moduli of bowel tumours obtained by the proposed models were applied to FE models and then generated force–displacement curves to compare with experiments. Our comparative analysis shows that FE results are in good agreement with experimental results. The proposed method can be potentially used in real time for detecting early bowel cancer by using a capsule robot when self-propelling in the bowel. | en_GB |
dc.description.sponsorship | Engineering and Physical Sciences Research Council (EPSRC) | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.description.sponsorship | China Scholarship Council | en_GB |
dc.description.sponsorship | National Natural Science Foundation of China | en_GB |
dc.format.extent | 105148-105148 | |
dc.identifier.citation | Article 105148 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.euromechsol.2023.105148 | |
dc.identifier.grantnumber | EP/V047868/1 | en_GB |
dc.identifier.grantnumber | IEC/NSFC/201059 | en_GB |
dc.identifier.grantnumber | 201908060172 | en_GB |
dc.identifier.grantnumber | 202006290118 | en_GB |
dc.identifier.grantnumber | 11932001 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/134079 | |
dc.identifier | ORCID: 0000-0003-3867-5137 (Liu, Yang) | |
dc.identifier | ScopusID: 55199382800 (Liu, Yang) | |
dc.identifier | ResearcherID: ABD-4124-2021 | K-1976-2015 (Liu, Yang) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | © 2023 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | en_GB |
dc.subject | Young’s modulus | en_GB |
dc.subject | Bowel cancer | en_GB |
dc.subject | Capsule robot | en_GB |
dc.subject | Hertz contact theory | en_GB |
dc.subject | Biomechanics | en_GB |
dc.title | Modelling and experimental investigation of capsule-tumour contact for early bowel cancer detection | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-09-25T08:42:09Z | |
dc.identifier.issn | 0997-7538 | |
exeter.article-number | 105148 | |
dc.description | This is the author accepted manuscript. The final version is available on open access from Elsevier via the DOI in this record | en_GB |
dc.description | Data availability: Data will be made available on request. | en_GB |
dc.identifier.journal | European Journal of Mechanics - A/Solids | en_GB |
dc.relation.ispartof | European Journal of Mechanics - A/Solids | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-09-21 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2023-09-23 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-09-25T08:38:50Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2023-09-25T08:42:12Z | |
refterms.panel | B | en_GB |
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Except where otherwise noted, this item's licence is described as © 2023 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)