The utility of the reperfusion rate of tissue oxygen saturation as a measure of vascular endothelial function in adolescents: reliability, validity and sensitivity
dc.contributor.author | Kranen, SH | |
dc.contributor.author | Oliveira, RS | |
dc.contributor.author | Bond, B | |
dc.contributor.author | Williams, CA | |
dc.contributor.author | Barker, AR | |
dc.date.accessioned | 2023-10-11T14:34:14Z | |
dc.date.issued | 2023-09-13 | |
dc.date.updated | 2023-10-11T14:03:16Z | |
dc.description.abstract | Introduction: The near-infrared spectroscopy (NIRS)-derived reperfusion rate of tissue oxygen saturation (slope 2 StO2) may provide a surrogate measure of vascular function, however, this has yet to be examined in a paediatric population. This study investigated in adolescents: 1) the between-day reliability of NIRS-derived measurements; 2) the relationship between slope 2 StO2 and macro- (flow-mediated dilation, FMD) and microvascular (peak reactive hyperaemia, PRH) function; and 3) the effect of high-intensity interval exercise (HIIE) on slope 2 StO2, FMD, and PRH. Methods: Nineteen boys (13.3 ± 0.5 y) visited the laboratory on two occasions, separated by ∼ 1 week. On visit 1, participants underwent simultaneous assessment of brachial artery FMD and slope 2 StO2 and PRH on the internal face of the forearm. On visit 2, participants completed a bout of HIIE with slope 2 StO2, FMD and PRH measured pre-, immediately post- and 1.5 h post-exercise. Results: Slope 2 StO2 showed no mean bias (p = 0.18) and an intraclass correlation coefficient of 0.67 (p = 0.003) between visits. No significant correlation between slope 2 StO2 and FMD or PRH was observed on visit 1 (r = -0.04, p = 0.89 and r = -0.30, p = 0.23, respectively) or visit 2 pre-exercise (r = -0.28, p = 0.25 and r = -0.31, p = 0.20, respectively). Compared to pre-exercise, FMD decreased immediately post-exercise (p < 0.001) and then increased 1.5 h post-exercise (p < 0.001). No significant change was detected for slope 2 StO2 (p = 0.30) or PRH (p = 0.55) following HIIE. Conclusion: In adolescents, slope 2 StO2 can be measured reliably, however, it is not correlated with FMD or PRH and does not follow the acute time course of changes in FMD post-exercise. Hence, the use of slope 2 StO2 as a surrogate measure of vascular function in youth must be refuted. | en_GB |
dc.identifier.citation | Vol. 14, article 1163474 | en_GB |
dc.identifier.doi | https://doi.org/10.3389/fphys.2023.1163474 | |
dc.identifier.uri | http://hdl.handle.net/10871/134210 | |
dc.identifier | ORCID: 0000-0001-8610-5417 (Barker, Alan R) | |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Media | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37781222 | en_GB |
dc.rights | © 2023 Kranen, Oliveira, Bond, Williams and Barker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_GB |
dc.subject | FMD | en_GB |
dc.subject | NIRS | en_GB |
dc.subject | repeatability | en_GB |
dc.subject | vascular function | en_GB |
dc.subject | youth | en_GB |
dc.title | The utility of the reperfusion rate of tissue oxygen saturation as a measure of vascular endothelial function in adolescents: reliability, validity and sensitivity | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-10-11T14:34:14Z | |
dc.identifier.issn | 1664-042X | |
exeter.place-of-publication | Switzerland | |
dc.description | This is the final version. Available on open access from Frontiers Media via the DOI in this record. | en_GB |
dc.description | Data availability statement: The raw data supporting the conclusion of this article will be made available by the authors, without undue reservation. | en_GB |
dc.identifier.journal | Frontiers in Physiology | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-08-17 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-09-13 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-10-11T14:30:57Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-10-11T14:34:19Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-09-13 |
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