Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review.
dc.contributor.author | Wilkinson, K | |
dc.contributor.author | Koscien, CP | |
dc.contributor.author | Monteyne, AJ | |
dc.contributor.author | Wall, BT | |
dc.contributor.author | Stephens, FB | |
dc.date.accessioned | 2023-10-11T15:06:04Z | |
dc.date.issued | 2023-08-03 | |
dc.date.updated | 2023-10-11T14:54:24Z | |
dc.description.abstract | BACKGROUND: Dietary protein ingestion augments post (resistance) exercise muscle protein synthesis (MPS) rates. It is thought that the dose of leucine ingested within the protein (leucine threshold hypothesis) and the subsequent plasma leucine variables (leucine trigger hypothesis; peak magnitude, rate of rise, and total availability) determine the magnitude of the postprandial postexercise MPS response. METHODS: A quantitative systematic review was performed extracting data from studies that recruited healthy adults, applied a bout of resistance exercise, ingested a bolus of protein within an hour of exercise, and measured plasma leucine concentrations and MPS rates (delta change from basal). RESULTS: Ingested leucine dose was associated with the magnitude of the MPS response in older, but not younger, adults over acute (0-2 h, r2 = 0.64, p = 0.02) and the entire postprandial (>2 h, r2 = 0.18, p = 0.01) period. However, no single plasma leucine variable possessed substantial predictive capacity over the magnitude of MPS rates in younger or older adults. CONCLUSION: Our data provide support that leucine dose provides predictive capacity over postprandial postexercise MPS responses in older adults. However, no threshold in older adults and no plasma leucine variable was correlated with the magnitude of the postexercise anabolic response. | en_GB |
dc.description.sponsorship | Beachbody LLC | en_GB |
dc.format.extent | e15775- | |
dc.format.medium | ||
dc.identifier.citation | Vol. 11, No. 15, article e15775 | en_GB |
dc.identifier.doi | https://doi.org/10.14814/phy2.15775 | |
dc.identifier.grantnumber | 111119G002 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/134215 | |
dc.identifier | ORCID: 0000-0002-6019-6709 (Wall, Benjamin T) | |
dc.identifier | ORCID: 0000-0001-6312-5351 (Stephens, Francis B) | |
dc.identifier | ScopusID: 12779890700 (Stephens, Francis B) | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37537134 | en_GB |
dc.rights | © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | amino acids | en_GB |
dc.subject | exercise | en_GB |
dc.subject | leucine | en_GB |
dc.subject | muscle protein synthesis | en_GB |
dc.subject | protein | en_GB |
dc.title | Association of postprandial postexercise muscle protein synthesis rates with dietary leucine: A systematic review. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-10-11T15:06:04Z | |
dc.identifier.issn | 2051-817X | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available from Wiley via the DOI in this record. | en_GB |
dc.description | DATA AVAILABILITY STATEMENT: The datasets generated and/or analyzed during the study implementation are available from the corresponding author upon request. | en_GB |
dc.identifier.journal | Physiological Reports | en_GB |
dc.relation.ispartof | Physiol Rep, 11(15) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-07-05 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-08-05 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-10-11T15:03:28Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-10-11T15:06:04Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-08-03 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited.