Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series
dc.contributor.author | Brown, M | |
dc.contributor.author | O'Connor, D | |
dc.contributor.author | Turkington, R | |
dc.contributor.author | Eatock, M | |
dc.contributor.author | Vince, R | |
dc.contributor.author | Hulme, C | |
dc.contributor.author | Bowdery, R | |
dc.contributor.author | Robinson, R | |
dc.contributor.author | Wadsley, J | |
dc.contributor.author | Maraveyas, A | |
dc.contributor.author | Prue, G | |
dc.date.accessioned | 2023-10-24T13:54:02Z | |
dc.date.issued | 2023-09-21 | |
dc.date.updated | 2023-10-24T12:07:55Z | |
dc.description.abstract | INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise training has shown promise is helping to manage such adversities and facilitate rehabilitation. The feasibility and safety of exercise training as a supportive therapy during adjuvant chemotherapy remains unknown. METHODS: Patients with PDAC were screened post-surgical resection and enrolled in a 16-week, progressive, concurrent exercise programme alongside their chemotherapy regimen. Feasibility was the primary objective detailing recruitment, retention and adherence rates throughout as well as the safety and fidelity of the intervention. Secondarily, the impact on functional fitness and patient-reported outcomes was captured at baseline, post-intervention and 3-month follow up. RESULTS: Eight patients consented to participate in this trial, with five proceeding to enrol in exercise training. Concurrent exercise training is feasible and safe during adjuvant chemotherapy and prevented an expected decline in functional fitness and patient-reported outcomes during this time. DISCUSSION: This case series provides preliminary evidence that concurrent exercise training during adjuvant therapy is safe, feasible and well tolerated, preventing an expected decline in functional fitness, muscular strength and health-related quality of life (HRQoL). Given the adverse effects of treatment, these findings are promising and provide further evidence for the inclusion of exercise training as a standard of care for surgical rehabilitation and managing treatment-related toxicities. Future research should explore the impact of exercise training during neoadjuvant chemotherapy, with prehabilitation now standard practice for borderline resectable disease. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04305067, prospectively registered 12/03/2020, https://classic. CLINICALTRIALS: gov/ct2/show/NCT04305067 . | en_GB |
dc.description.sponsorship | Pancreatic Cancer UK | en_GB |
dc.format.extent | 116- | |
dc.format.medium | Electronic | |
dc.identifier.citation | Vol. 15, article 116 | en_GB |
dc.identifier.doi | https://doi.org/10.1186/s13102-023-00722-3 | |
dc.identifier.uri | http://hdl.handle.net/10871/134319 | |
dc.identifier | ORCID: 0000-0003-2077-0419 (Hulme, Claire) | |
dc.language.iso | en | en_GB |
dc.publisher | BMC | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37735664 | en_GB |
dc.rights | © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data | en_GB |
dc.subject | Exercise | en_GB |
dc.subject | Feasibility | en_GB |
dc.subject | Functional fitness | en_GB |
dc.subject | Pancreatic ductal adenocarcinoma | en_GB |
dc.subject | Patient-reported outcomes | en_GB |
dc.title | Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-10-24T13:54:02Z | |
dc.identifier.issn | 2052-1847 | |
exeter.article-number | 116 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from BMC via the DOI in this record | en_GB |
dc.description | Data Availability: Data generated during this study is available from the corresponding author on reasonable request. | en_GB |
dc.identifier.eissn | 2052-1847 | |
dc.identifier.journal | BMC Sports Science, Medicine and Rehabilitation | en_GB |
dc.relation.ispartof | BMC Sports Sci Med Rehabil, 15(1) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-09-05 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-09-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-10-24T13:52:41Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-10-24T13:54:07Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-09-21 |
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in this article, unless otherwise stated in a credit line to the data