A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease.
dc.contributor.author | Alvergne, A | |
dc.contributor.author | Kountourides, G | |
dc.contributor.author | Argentieri, MA | |
dc.contributor.author | Agyen, L | |
dc.contributor.author | Rogers, N | |
dc.contributor.author | Knight, D | |
dc.contributor.author | Sharp, GC | |
dc.contributor.author | Maybin, JA | |
dc.contributor.author | Olszewska, Z | |
dc.date.accessioned | 2023-11-01T09:49:47Z | |
dc.date.issued | 2023-03-21 | |
dc.date.updated | 2023-10-31T16:59:39Z | |
dc.description.abstract | There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. Our objectives were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease. We performed a secondary analysis of a retrospective online survey conducted in the UK in March 2021. In pre-menopausal vaccinated participants (n = 4,989), 18% reported menstrual cycle changes after their first COVID-19 vaccine injection. The prevalence of reporting any menstrual changes was higher for women who smoke, have a history of COVID-19 disease, or are not using estradiol-containing contraceptives. In a second sample including both vaccinated and unvaccinated participants (n = 12,579), COVID-19 vaccination alone was not associated with abnormal menstrual cycle parameters, while a history of COVID-19 disease was associated with an increased risk of reporting heavier bleeding, "missed" periods, and inter-menstrual bleeding. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Royal Society of Edinburgh | en_GB |
dc.description.sponsorship | Medical Research Center | en_GB |
dc.description.sponsorship | Medical Research Center | en_GB |
dc.description.sponsorship | British Academy | en_GB |
dc.description.sponsorship | Economic and Social Research Council (ESRC) | en_GB |
dc.format.extent | 106401- | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 26, No. 4, article 106401 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.isci.2023.106401 | |
dc.identifier.grantnumber | 209589/Z/17/Z | en_GB |
dc.identifier.grantnumber | IS3-R3.11 21/22 | en_GB |
dc.identifier.grantnumber | 1077 | en_GB |
dc.identifier.grantnumber | G1002033 | en_GB |
dc.identifier.grantnumber | MR/N022556/1 | en_GB |
dc.identifier.grantnumber | MD19\190016 | en_GB |
dc.identifier.grantnumber | ES/P000649/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/134377 | |
dc.identifier | ORCID: 0000-0003-2906-4035 (Sharp, Gemma C) | |
dc.identifier | ScopusID: 56898577600 (Sharp, Gemma C) | |
dc.language.iso | en | en_GB |
dc.publisher | Cell Press | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/36987520 | en_GB |
dc.rights | © 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | en_GB |
dc.subject | Health sciences | en_GB |
dc.subject | Immunology | en_GB |
dc.subject | Public health | en_GB |
dc.subject | Women's health | en_GB |
dc.title | A retrospective case-control study on menstrual cycle changes following COVID-19 vaccination and disease. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-11-01T09:49:47Z | |
dc.identifier.issn | 2589-0042 | |
exeter.article-number | 106401 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available from Cell Press via the DOI in this record. | en_GB |
dc.identifier.journal | iScience | en_GB |
dc.relation.ispartof | iScience, 26(4) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-03-09 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-03-21 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-11-01T09:44:31Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-11-01T09:49:54Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-03-21 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)