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dc.contributor.authorStevenson, EM
dc.contributor.authorBuckling, A
dc.contributor.authorCole, M
dc.contributor.authorLindeque, PK
dc.contributor.authorMurray, AK
dc.date.accessioned2023-11-10T09:27:46Z
dc.date.issued2023-11-02
dc.date.updated2023-11-09T19:28:40Z
dc.description.abstractMicroplastics and antimicrobials are widespread contaminants that threaten global systems and frequently co-exist in the presence of human or animal pathogens. Whilst the impact of each of these contaminants has been studied in isolation, the influence of this co-occurrence in driving antimicrobial resistance (AMR)1 in microplastic-adhered microbial communities, known as 'the Plastisphere', is not well understood. This review proposes the mechanisms by which interactions between antimicrobials and microplastics may drive selection for AMR in the Plastisphere. These include: 1) increased rates of horizontal gene transfer in the Plastisphere compared with free-living counterparts and natural substrate controls due to the proximity of cells, co-occurrence of environmental microplastics with AMR selective compounds and the sequestering of extracellular antibiotic resistance genes in the biofilm matrix. 2) An elevated AMR selection pressure in the Plastisphere due to the adsorbing of AMR selective or co-selective compounds to microplastics at concentrations greater than those found in surrounding mediums and potentially those adsorbed to comparator particles. 3) AMR selection pressure may be further elevated in the Plastisphere due to the incorporation of antimicrobial or AMR co-selective chemicals in the plastic matrix during manufacture. Implications for both ecological functioning and environmental risk assessments are discussed, alongside recommendations for further research.en_GB
dc.description.sponsorshipNatural Environment Research Council (NERC)en_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.description.sponsorshipMelissa Murdochen_GB
dc.description.sponsorshipBarnsbury Trusten_GB
dc.description.sponsorshipBeach Guardianen_GB
dc.identifier.citationVol. 908, article 168234en_GB
dc.identifier.doihttps://doi.org/10.1016/j.scitotenv.2023.168234
dc.identifier.grantnumberNE/W006251/1en_GB
dc.identifier.grantnumberNE/V007351/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/134483
dc.identifierORCID: 0000-0002-1388-754X (Murray, Aimee K)
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/37924893en_GB
dc.rights© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_GB
dc.subjectAntimicrobial resistanceen_GB
dc.subjectBiofilmen_GB
dc.subjectEvolutionen_GB
dc.subjectMicroplasticen_GB
dc.subjectPlastisphereen_GB
dc.subjectPollutionen_GB
dc.titleSelection for antimicrobial resistance in the plastisphereen_GB
dc.typeArticleen_GB
dc.date.available2023-11-10T09:27:46Z
dc.identifier.issn0048-9697
exeter.article-number168234
exeter.place-of-publicationNetherlands
dc.descriptionThis is the final version. Available on open access from Elsevier via the DOI in this record. en_GB
dc.descriptionData availability: No data was used for the research described in the article.en_GB
dc.identifier.eissn1879-1026
dc.identifier.journalScience of the Total Environmenten_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-10-29
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2023-11-02
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-11-10T09:23:59Z
refterms.versionFCDVoR
refterms.dateFOA2023-11-10T09:28:09Z
refterms.panelAen_GB
refterms.dateFirstOnline2023-11-02


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© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's licence is described as © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).