Selection for antimicrobial resistance in the plastisphere
dc.contributor.author | Stevenson, EM | |
dc.contributor.author | Buckling, A | |
dc.contributor.author | Cole, M | |
dc.contributor.author | Lindeque, PK | |
dc.contributor.author | Murray, AK | |
dc.date.accessioned | 2023-11-10T09:27:46Z | |
dc.date.issued | 2023-11-02 | |
dc.date.updated | 2023-11-09T19:28:40Z | |
dc.description.abstract | Microplastics and antimicrobials are widespread contaminants that threaten global systems and frequently co-exist in the presence of human or animal pathogens. Whilst the impact of each of these contaminants has been studied in isolation, the influence of this co-occurrence in driving antimicrobial resistance (AMR)1 in microplastic-adhered microbial communities, known as 'the Plastisphere', is not well understood. This review proposes the mechanisms by which interactions between antimicrobials and microplastics may drive selection for AMR in the Plastisphere. These include: 1) increased rates of horizontal gene transfer in the Plastisphere compared with free-living counterparts and natural substrate controls due to the proximity of cells, co-occurrence of environmental microplastics with AMR selective compounds and the sequestering of extracellular antibiotic resistance genes in the biofilm matrix. 2) An elevated AMR selection pressure in the Plastisphere due to the adsorbing of AMR selective or co-selective compounds to microplastics at concentrations greater than those found in surrounding mediums and potentially those adsorbed to comparator particles. 3) AMR selection pressure may be further elevated in the Plastisphere due to the incorporation of antimicrobial or AMR co-selective chemicals in the plastic matrix during manufacture. Implications for both ecological functioning and environmental risk assessments are discussed, alongside recommendations for further research. | en_GB |
dc.description.sponsorship | Natural Environment Research Council (NERC) | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Melissa Murdoch | en_GB |
dc.description.sponsorship | Barnsbury Trust | en_GB |
dc.description.sponsorship | Beach Guardian | en_GB |
dc.identifier.citation | Vol. 908, article 168234 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.scitotenv.2023.168234 | |
dc.identifier.grantnumber | NE/W006251/1 | en_GB |
dc.identifier.grantnumber | NE/V007351/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/134483 | |
dc.identifier | ORCID: 0000-0002-1388-754X (Murray, Aimee K) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37924893 | en_GB |
dc.rights | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | Antimicrobial resistance | en_GB |
dc.subject | Biofilm | en_GB |
dc.subject | Evolution | en_GB |
dc.subject | Microplastic | en_GB |
dc.subject | Plastisphere | en_GB |
dc.subject | Pollution | en_GB |
dc.title | Selection for antimicrobial resistance in the plastisphere | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-11-10T09:27:46Z | |
dc.identifier.issn | 0048-9697 | |
exeter.article-number | 168234 | |
exeter.place-of-publication | Netherlands | |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record. | en_GB |
dc.description | Data availability: No data was used for the research described in the article. | en_GB |
dc.identifier.eissn | 1879-1026 | |
dc.identifier.journal | Science of the Total Environment | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-10-29 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-11-02 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-11-10T09:23:59Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-11-10T09:28:09Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-11-02 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).