Multi-locus homozygosity promotes actuarial senescence in a wild mammal.
dc.contributor.author | Hudson, DW | |
dc.contributor.author | McKinley, TJ | |
dc.contributor.author | Benton, CH | |
dc.contributor.author | Delahay, R | |
dc.contributor.author | McDonald, RA | |
dc.contributor.author | Hodgson, DJ | |
dc.date.accessioned | 2023-11-29T11:31:50Z | |
dc.date.issued | 2023-07-10 | |
dc.date.updated | 2023-11-29T10:53:21Z | |
dc.description.abstract | Genome-wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will filter out negative impacts on younger individuals with greater reproductive value. Here we infer associations between multi-locus homozygosity (MLH), sex, disease and age-dependent mortality risks using Bayesian analysis of the life histories of wild European badgers Meles meles in a population naturally infected with Mycobacterium bovis (the causative agent of bovine tuberculosis [bTB]). We find important effects of MLH on all parameters of the Gompertz-Makeham mortality hazard function, but particularly in later life. Our findings confirm the predicted association between genomic homozygosity and actuarial senescence. Increased homozygosity is particularly associated with an earlier onset, and greater rates of actuarial senescence, regardless of sex. The association between homozygosity and actuarial senescence is further amplified among badgers putatively infected with bTB. These results recommend further investigation into the ecological and behavioural processes that result in genome-wide homozygosity, and focused work on whether homozygosity is harmful or beneficial during early life-stages. | en_GB |
dc.description.sponsorship | Natural Environment Research Council (NERC) | en_GB |
dc.description.sponsorship | Natural Environment Research Council (NERC) | en_GB |
dc.description.sponsorship | Animal and Plant Health Agency | en_GB |
dc.description.sponsorship | Expanding Excellence in England | en_GB |
dc.description.sponsorship | University of Exeter | en_GB |
dc.format.extent | 1881-1892 | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 92, No. 9, pp. 1881-1892 | en_GB |
dc.identifier.doi | https://doi.org/10.1111/1365-2656.13979 | |
dc.identifier.grantnumber | NE/M010260/1 | en_GB |
dc.identifier.grantnumber | NE/V000616/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/134687 | |
dc.identifier | ORCID: 0000-0002-9485-3236 (McKinley, Trevelyan J) | |
dc.identifier | ORCID: 0000-0002-6922-3195 (McDonald, Robbie A) | |
dc.identifier | ORCID: 0000-0003-4220-2076 (Hodgson, Dave J) | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley / British Ecological Society | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37427855 | en_GB |
dc.relation.url | https://doi.org/10.5061/dryad.bk3j9kdg6 | en_GB |
dc.rights | © 2023 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Bayesian | en_GB |
dc.subject | inbreeding | en_GB |
dc.subject | mortality trajectory | en_GB |
dc.subject | multi-locus homozygosity | en_GB |
dc.subject | reverse jump Markov Chain Monte Carlo | en_GB |
dc.subject | survival analysis | en_GB |
dc.subject | wildlife disease | en_GB |
dc.title | Multi-locus homozygosity promotes actuarial senescence in a wild mammal. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2023-11-29T11:31:50Z | |
dc.identifier.issn | 0021-8790 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available from Wiley via the DOI in this record. | en_GB |
dc.description | DATA AVAILABILITY STATEMENT: Data available from the Dryad Digital Repository https://doi. org/10.5061/dryad.bk3j9kdg6 (Hudson, 2023) | en_GB |
dc.identifier.eissn | 1365-2656 | |
dc.identifier.journal | Journal of Animal Ecology | en_GB |
dc.relation.ispartof | J Anim Ecol, 92(9) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-06-05 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-07-10 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2023-11-29T11:28:44Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2023-11-29T11:31:55Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-07-10 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Journal of Animal Ecology published by John Wiley & Sons Ltd on behalf of British Ecological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.