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dc.contributor.authorTakesono, A
dc.contributor.authorDimitriadou, S
dc.contributor.authorClark, NJ
dc.contributor.authorHandy, RD
dc.contributor.authorMourabit, S
dc.contributor.authorWinter, MJ
dc.contributor.authorKudoh, T
dc.contributor.authorTyler, CR
dc.date.accessioned2023-12-18T12:20:15Z
dc.date.issued2023-10-10
dc.date.updated2023-12-17T15:56:25Z
dc.description.abstractZinc (Zn) is an essential metal present in numerous enzymes throughout the body, playing a vital role in animal and human health. However, the increasing use of zinc oxide nanomaterials (ZnONPs) in a diverse range of products has raised concerns regarding their potential impacts on health and the environment. Despite these concerns, the toxicity of ZnONP exposure on animal health remain poorly understood. To help address this knowledge gap, we have developed a highly sensitive oxidative stress (OS) biosensor zebrafish capable of detecting cell/tissue-specific OS responses to low doses of various oxidative stressors, including Zn, in a live fish embryo. Using live-imaging analysis with this biosensor zebrafish embryo, we discovered that the olfactory sensory neurons in the brain are especially sensitive to ZnOP exposure. Furthermore, through studies monitoring neutrophil migration and neuronal activation in the embryonic brain and via behaviour analysis, we have found that sub-lethal doses of ZnONPs (ranging from 0.033 to 1 mg/L nominal concentrations), which had no visible effect on embryo growth or morphology, cause significant localised inflammation, disrupting the neurophysiology of olfactory brain tissues and ultimately impaired olfaction-mediated behaviour. Collectively, these findings establish a potent and important effect mechanism for ZnONP toxicity, indicating the olfactory sensory system as the primary target for ZnONPs as an environmental toxicant in aquatic environments. Our result also highlights that even low doses of ZnONPs can have detrimental effects on the olfactory sensory system, surpassing previous expectations. The importance of olfaction in environment sensing, sex behaviours and overall fitness across species raises concerns about the potential impact of ZnONPs on olfaction-mediated brain function and behaviour in animals and humans. Our study emphasises the need for greater consideration of the potential risks associated with these nanomaterials.en_GB
dc.description.sponsorshipNatural Environment Research Council (NERC)en_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.description.sponsorshipEuropean Union Horizon 2020en_GB
dc.format.extent108227-
dc.format.mediumPrint-Electronic
dc.identifier.citationVol. 180, article 108227en_GB
dc.identifier.doihttps://doi.org/10.1016/j.envint.2023.108227
dc.identifier.grantnumberNE/L007371/1en_GB
dc.identifier.grantnumberBB/L020637/1en_GB
dc.identifier.grantnumber760813en_GB
dc.identifier.urihttp://hdl.handle.net/10871/134813
dc.identifierORCID: 0000-0001-8270-6389 (Dimitriadou, Sylvia)
dc.identifierORCID: 0000-0002-1196-0483 | 0000-0002-3668-6564 (Winter, Matthew J)
dc.identifierScopusID: 7202444342 (Winter, Matthew J)
dc.identifierORCID: 0000-0002-5373-2737 (Kudoh, Tetsuhiro)
dc.identifierORCID: 0000-0003-2353-5748 (Tyler, Charles R)
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/37826893en_GB
dc.rights/© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)en_GB
dc.subjectAdverse Outcome Pathway (AOP)en_GB
dc.subjectBiosensor transgenic zebrafishen_GB
dc.subjectDevelopmental neurotoxicityen_GB
dc.subjectNano-metal pollutionen_GB
dc.subjectOxidative stressen_GB
dc.titleZinc oxide nanoparticles disrupt development and function of the olfactory sensory system impairing olfaction-mediated behaviour in zebrafishen_GB
dc.typeArticleen_GB
dc.date.available2023-12-18T12:20:15Z
dc.identifier.issn0160-4120
exeter.article-number108227
exeter.place-of-publicationNetherlands
dc.descriptionThis is the final version. Available on open access from Elsevier via the DOI in this recorden_GB
dc.descriptionData availability: Data will be made available on request.en_GB
dc.identifier.eissn1873-6750
dc.identifier.journalEnviron Inten_GB
dc.relation.ispartofEnviron Int, 180
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-09-20
dc.rights.licenseCC BY
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2023-10-10
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2023-12-18T12:17:04Z
refterms.versionFCDVoR
refterms.dateFOA2023-12-18T12:20:16Z
refterms.panelAen_GB


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/© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Except where otherwise noted, this item's licence is described as /© 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)