The effects of partial sleep restriction and subsequent caffeine ingestion on neurovascular coupling

Abstract

Habitual poor sleep is associated with cerebrovascular disease. Acute sleep deprivation alters the ability to match brain blood flow to metabolism (neurovascular coupling, NVC) but it is not known how partial sleep restriction affects NVC. When rested, caffeine disrupts NVC, but its effects in the sleep restricted state are unknown. The purpose of this study was therefore to investigate the effects of partial sleep restriction and subsequent caffeine ingestion on NVC. Seventeen adults (age 27±5 years, 9 female) completed three separate overnight conditions with morning supplementation: habitual sleep plus placebo (Norm_Pl), habitual sleep plus caffeine (Norm_Caf), and partial (50% habitual sleep) restriction plus caffeine (PSR_Caf). NVC responses were quantified as blood velocity through the posterior (PCAv) and middle (MCAv) cerebral arteries using transcranial Doppler ultrasound during a visual search task and cognitive function tests, respectively. NVC was assessed the evening before and twice the morning after each sleep condition – pre- and 1-hour post caffeine ingestion. NVC responses as a percent increase in PCAv and MCAv from resting baseline were not different at any timepoint, across all conditions (P>0.053). MCAv at baseline, and PCAv at baseline, peak, and total AUC were lower 1-hour after caffeine in both Norm_Caf and PSR_Caf as compared to Norm_Pl (P<0.05), with no difference between Norm_Caf and PSR_Caf (P>0.14). In conclusion, NVC was unaltered after 50% sleep loss, and caffeine did not modify the magnitude of the response in the rested or sleep deprived state. Future research should explore how habitual poor sleep affects cerebrovascular function.