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A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

dc.contributor.authorLi, S
dc.contributor.authorSpitz, N
dc.contributor.authorGhantous, A
dc.contributor.authorAbrishamcar, S
dc.contributor.authorReimann, B
dc.contributor.authorMarques, I
dc.contributor.authorSilver, MJ
dc.contributor.authorAguilar-Lacasaña, S
dc.contributor.authorKitaba, N
dc.contributor.authorRezwan, FI
dc.contributor.authorRöder, S
dc.contributor.authorSirignano, L
dc.contributor.authorTuhkanen, J
dc.contributor.authorMancano, G
dc.contributor.authorSharp, GC
dc.contributor.authorMetayer, C
dc.contributor.authorMorimoto, L
dc.contributor.authorStein, DJ
dc.contributor.authorZar, HJ
dc.contributor.authorAlfano, R
dc.contributor.authorNawrot, T
dc.contributor.authorWang, C
dc.contributor.authorKajantie, E
dc.contributor.authorKeikkala, E
dc.contributor.authorMustaniemi, S
dc.contributor.authorRonkainen, J
dc.contributor.authorSebert, S
dc.contributor.authorSilva, W
dc.contributor.authorVääräsmäki, M
dc.contributor.authorJaddoe, VWV
dc.contributor.authorBernstein, RM
dc.contributor.authorPrentice, AM
dc.contributor.authorCosin-Tomas, M
dc.contributor.authorDwyer, T
dc.contributor.authorHåberg, SE
dc.contributor.authorHerceg, Z
dc.contributor.authorMagnus, MC
dc.contributor.authorMunthe-Kaas, MC
dc.contributor.authorPage, CM
dc.contributor.authorVölker, M
dc.contributor.authorGilles, M
dc.contributor.authorSend, T
dc.contributor.authorWitt, S
dc.contributor.authorZillich, L
dc.contributor.authorGagliardi, L
dc.contributor.authorRichiardi, L
dc.contributor.authorCzamara, D
dc.contributor.authorRäikkönen, K
dc.contributor.authorChatzi, L
dc.contributor.authorVafeiadi, M
dc.contributor.authorArshad, SH
dc.contributor.authorEwart, S
dc.contributor.authorPlusquin, M
dc.contributor.authorFelix, JF
dc.contributor.authorMoore, SE
dc.contributor.authorVrijheid, M
dc.contributor.authorHolloway, JW
dc.contributor.authorKarmaus, W
dc.contributor.authorHerberth, G
dc.contributor.authorZenclussen, A
dc.contributor.authorStreit, F
dc.contributor.authorLahti, J
dc.contributor.authorHüls, A
dc.contributor.authorHoang, TT
dc.contributor.authorLondon, SJ
dc.contributor.authorWiemels, JL
dc.date.accessioned2024-01-10T15:55:03Z
dc.date.issued2024-01-09
dc.date.updated2024-01-10T14:16:47Z
dc.description.abstractHigher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.en_GB
dc.description.sponsorshipNational Institute of Environmental Health Sciencesen_GB
dc.description.sponsorshipNational Cancer Instituteen_GB
dc.description.sponsorshipUS Environmental Protection Agencyen_GB
dc.identifier.citationVol. 7(1), article 66en_GB
dc.identifier.doihttps://doi.org/10.1038/s42003-023-05698-x
dc.identifier.grantnumberP01ES018172en_GB
dc.identifier.grantnumberR01ES09137en_GB
dc.identifier.grantnumberR01CA185058en_GB
dc.identifier.grantnumberR01CA175737en_GB
dc.identifier.grantnumberRD83451101en_GB
dc.identifier.grantnumberRD83615901en_GB
dc.identifier.urihttp://hdl.handle.net/10871/134981
dc.identifierORCID: 0000-0003-2906-4035 (Sharp, Gemma C)
dc.identifierScopusID: 56898577600 (Sharp, Gemma C)
dc.language.isoenen_GB
dc.publisherNature Researchen_GB
dc.rights© The Author(s) 2024. Open access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/en_GB
dc.titleA Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylationen_GB
dc.typeArticleen_GB
dc.date.available2024-01-10T15:55:03Z
exeter.article-number66
dc.descriptionThis is the final version. Available on open access from Nature Research via the DOI in this recorden_GB
dc.descriptionData availability: Blood samples and raw genetic data of neonatal subjects from each cohort are governed by their respective institutions and/or government agencies, and mostly could not be shared publicly without specific approvals. For example, for data from first author cohort, California Childhood Leukemia Study (CCLS), we respectfully are unable to share raw, individual genetic data freely with other investigators. Should we be contacted by other investigators who would like to use the data; we will direct them to the California Department of Public Health Institutional Review Board to establish their own approved protocol to utilize the data, which can then be shared peer-to-peer.en_GB
dc.identifier.eissn2399-3642
dc.identifier.journalCommunications Biologyen_GB
dc.relation.ispartofCommunications Biology, 7(1)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-12-12
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2024-01-09
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2024-01-10T15:51:50Z
refterms.versionFCDVoR
refterms.dateFOA2024-01-10T15:55:07Z
refterms.panelAen_GB
refterms.dateFirstOnline2024-01-09


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© The Author(s) 2024. Open access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © The Author(s) 2024. Open access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/