Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme
dc.contributor.author | Martyr, A | |
dc.contributor.author | Ravi, M | |
dc.contributor.author | Gamble, LD | |
dc.contributor.author | Morris, RG | |
dc.contributor.author | Rusted, JM | |
dc.contributor.author | Pentecost, C | |
dc.contributor.author | Matthews, FE | |
dc.contributor.author | Clare, L | |
dc.contributor.author | IDEAL study team | |
dc.date.accessioned | 2024-01-18T13:06:34Z | |
dc.date.issued | 2023-09-02 | |
dc.date.updated | 2024-01-17T16:34:09Z | |
dc.description.abstract | INTRODUCTION: Impaired cognition and instrumental activities of daily living (iADL) are key diagnostic features of dementia; however, few studies have compared trajectories of cognition and iADL. METHODS: Participants from the IDEAL study comprised 1537, 1183, and 851 people with dementia, and 1277, 977, and 749 caregivers at baseline, 12 and 24 months, respectively. Addenbrooke's Cognitive Examination-III and Functional Activities Questionnaire were used to measure cognition and iADL, respectively. Scores were converted to deciles. RESULTS: Self-rated iADL declined on average by -0.08 (-0.25, 0.08) decile points per timepoint more than cognition. Informant-rated iADL declined on average by -0.31 (-0.43, -0.18) decile points per timepoint more than cognition. DISCUSSION: Cognition and self-rated iADL declined at a similar rate. Informant-rated iADL declined at a significantly greater rate than cognition. Therefore, either cognition and perceived iADL decline at different rates or informants overestimate increasing iADL difficulties compared to both cognition and self-ratings. HIGHLIGHTS: Self-ratings of the degree of functional difficulties were consistent with cognition Decline in self-rated everyday activities was consistent with cognitive decline Informant-ratings of everyday activities declined more than cognition. | en_GB |
dc.description.sponsorship | Economic and Social Research Council (ESRC) | en_GB |
dc.description.sponsorship | National Institute for Health and Care Research (NIHR) | en_GB |
dc.description.sponsorship | Alzheimer’s Society | en_GB |
dc.identifier.citation | Vol. 20 (1), pp. 410-420 | en_GB |
dc.identifier.doi | https://doi.org/10.1002/alz.13448 | |
dc.identifier.grantnumber | 348, AS-PR2-16-001 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/135054 | |
dc.identifier | ORCID: 0000-0002-1702-8902 (Martyr, Anthony) | |
dc.identifier | ORCID: 0000-0003-2048-5538 (Pentecost, Claire) | |
dc.identifier | ORCID: 0000-0002-3740-5162 | 0000-0003-3989-5318 (Clare, Linda) | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley / Alzheimer’s Association | en_GB |
dc.relation.url | https://reshare.ukdataservice.ac.uk/854293/ | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/37658739 | en_GB |
dc.rights | © 2023 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Alzheimer's disease | en_GB |
dc.subject | instrumental activities of daily living | en_GB |
dc.subject | longitudinal | en_GB |
dc.subject | memory | en_GB |
dc.subject | rating accuracy | en_GB |
dc.title | Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-01-18T13:06:34Z | |
dc.identifier.issn | 1552-5260 | |
exeter.place-of-publication | United States | |
dc.description | This is the final version. Available on open access from Wiley via the DOI in this record | en_GB |
dc.description | Data availability statement: IDEAL data were deposited with the UK Data Archive in April 2020. Details of how the data can be accessed can be found here: https://reshare.ukdataservice.ac.uk/854293/ | en_GB |
dc.identifier.eissn | 1552-5279 | |
dc.identifier.journal | Alzheimer's & Dementia: The Journal of the Alzheimer's Association | en_GB |
dc.relation.ispartof | Alzheimers Dement | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-07-28 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-09-02 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-01-18T13:03:40Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-01-18T13:06:43Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-09-02 |
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Except where otherwise noted, this item's licence is described as © 2023 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited.