Assessing Ethnic Minority Representation in Fibromyalgia Clinical Trials: A Systematic Review of Recruitment Demographics
dc.contributor.author | Henley, P | |
dc.contributor.author | Martins, T | |
dc.contributor.author | Zamani, R | |
dc.date.accessioned | 2024-01-22T09:37:34Z | |
dc.date.issued | 2023-12-15 | |
dc.date.updated | 2024-01-21T02:51:49Z | |
dc.description.abstract | The under-representation of non-White participants in Western countries in clinical research has received increased attention, due to recognized physiological differences between ethnic groups, which may affect the efficacy and optimal dosage of some treatments. This review assessed ethnic diversity in pharmaceutical trials for fibromyalgia, a poorly understood chronic pain disorder. We also investigated longitudinal change to non-White participant proportions in trials and non-White participants' likelihood to discontinue with fibromyalgia research between trial stages (retention). First, we identified relevant trials conducted in the United States and Canada between 2000 and 2022, by searching PubMed, Web of Science, Scopus, and the Cochrane Library databases. In trials conducted both across the United States and Canada, and exclusively within the United States, approximately 90% of participants were White. A longitudinal analysis also found no change in the proportion of non-White participants in trials conducted across the United States and Canada between 2000 and 2022. Finally, we found no significant differences in trial retention between White and non-White participants. This review highlights the low numbers of ethnic minorities in fibromyalgia trials conducted in the United States and Canada, with no change to these proportions over the past 22 years. Furthermore, non-White participants were not more likely to discontinue with the fibromyalgia research once they were recruited. | en_GB |
dc.format.extent | 7185- | |
dc.format.medium | Electronic | |
dc.identifier.citation | Vol. 20(24), article 7185 | en_GB |
dc.identifier.doi | https://doi.org/10.3390/ijerph20247185 | |
dc.identifier.uri | http://hdl.handle.net/10871/135078 | |
dc.identifier | ORCID: 0000-0001-5226-4073 (Martins, Tanimola) | |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38131736 | en_GB |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_GB |
dc.subject | ethnic minorities | en_GB |
dc.subject | fibromyalgia | en_GB |
dc.subject | longitudinal | en_GB |
dc.subject | non-White | en_GB |
dc.subject | pharmaceutical | en_GB |
dc.subject | retention | en_GB |
dc.subject | trials | en_GB |
dc.subject | underrepresentation | en_GB |
dc.title | Assessing Ethnic Minority Representation in Fibromyalgia Clinical Trials: A Systematic Review of Recruitment Demographics | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-01-22T09:37:34Z | |
dc.identifier.issn | 1661-7827 | |
exeter.place-of-publication | Switzerland | |
dc.description | This is the final version. Available on open access from MDPI via the DOI in this record | en_GB |
dc.description | Data Availability Statement: Data used for analysis can be supplied from the corresponding author upon request. | en_GB |
dc.identifier.eissn | 1660-4601 | |
dc.identifier.journal | International Journal of Environmental Research and Public Health | en_GB |
dc.relation.ispartof | Int J Environ Res Public Health, 20(24) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2023-12-07 | |
dc.rights.license | CC BY | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2023-12-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-01-22T09:35:19Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-01-22T09:37:40Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2023-12-15 |
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Except where otherwise noted, this item's licence is described as © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).