dc.contributor.author | van der Heijden, I | |
dc.contributor.author | West, S | |
dc.contributor.author | Monteyne, AJ | |
dc.contributor.author | Finnigan, TJA | |
dc.contributor.author | Abdelrahman, DR | |
dc.contributor.author | Murton, AJ | |
dc.contributor.author | Stephens, FB | |
dc.contributor.author | Wall, BT | |
dc.date.accessioned | 2024-01-29T13:38:12Z | |
dc.date.issued | 2024-01-15 | |
dc.date.updated | 2024-01-29T11:15:08Z | |
dc.description.abstract | Whole-body tissue protein turnover is regulated, in part, by the postprandial rise in plasma amino acid concentrations, although minimal data exist on the amino acid response following non-animal-derived protein consumption. We hypothesised that the ingestion of novel plant- and algae-derived dietary protein sources would elicit divergent plasma amino acid responses when compared with vegan- and animal-derived control proteins. Twelve healthy young (male [m]/female [f]: 6/6; age: 22±1 y) and 10 healthy older (m/f: 5/5; age: 69±2 y) adults participated in a randomised, double-blind, crossover trial. During each visit, volunteers consumed 30 g protein from milk, mycoprotein, pea, lupin, spirulina or chlorella. Repeated arterialised venous blood samples were collected at baseline and over a 5 h postprandial period to assess circulating amino acid, glucose, and insulin concentrations. Protein ingestion increased plasma total and essential amino acid concentrations (P<0.001), to differing degrees between sources (P<0.001), and the increase was further modulated by age (P<0.001). Postprandial maximal plasma total and essential amino acid concentrations were highest for pea (2828±106 and 1480±51 µmol·L-1) and spirulina (2809±99 and 1455±49 µmol·L-1), and lowest for chlorella (2053±83 and 983±35 µmol·L-1) (P<0.001), but were not affected by age (P>0.05). Postprandial total and essential amino acid availabilities were highest for pea, spirulina and mycoprotein, and lowest for chlorella (all P<0.05), but no effect of age was observed (P>0.05). The ingestion of a variety of novel non-animal-derived dietary protein sources elicits divergent plasma amino acid responses, which are further modulated by age. | en_GB |
dc.format.extent | 1-34 | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Published online 15 January 2024 | en_GB |
dc.identifier.doi | https://doi.org/10.1017/S0007114524000163 | |
dc.identifier.uri | http://hdl.handle.net/10871/135196 | |
dc.identifier | ORCID: 0000-0002-6019-6709 (Wall, Benjamin T) | |
dc.language.iso | en | en_GB |
dc.publisher | Cambridge University Press | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38220222 | en_GB |
dc.rights.embargoreason | Under embargo until 15 July 2024 in compliance with publisher policy | en_GB |
dc.rights | © The Authors 2024 | en_GB |
dc.subject | Plant protein | en_GB |
dc.subject | ageing | en_GB |
dc.subject | algae | en_GB |
dc.subject | amino acids | en_GB |
dc.subject | bioavailability | en_GB |
dc.subject | mycoprotein | en_GB |
dc.title | Ingestion of a variety of non-animal-derived dietary protein sources results in diverse postprandial plasma amino acid responses which differ between young and older adults. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-01-29T13:38:12Z | |
dc.identifier.issn | 0007-1145 | |
exeter.place-of-publication | England | |
dc.description | Data availability:
Data described in the manuscript may be made available upon request, pending application. | en_GB |
dc.identifier.eissn | 1475-2662 | |
dc.identifier.journal | British Journal of Nutrition | en_GB |
dc.relation.ispartof | Br J Nutr | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2024-01-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-01-29T13:34:23Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-01-15 | |