Mediators of the effects of exercise and manual therapy for people with knee and hip osteoarthritis: A secondary, exploratory analysis of the MOA trial
dc.contributor.author | Ribeiro, DC | |
dc.contributor.author | Lamb, SE | |
dc.contributor.author | Abbott, JH | |
dc.date.accessioned | 2024-03-04T13:04:46Z | |
dc.date.issued | 2024-01-09 | |
dc.date.updated | 2024-03-04T12:11:45Z | |
dc.description.abstract | OBJECTIVE: To explore whether pain beliefs and functional strength mediate the treatment effect of manual therapy (MT) and exercise therapy (ET) on the Western Ontario and McMaster Osteoarthritis Index (WOMAC) composite scores and its subscales in individuals with hip and/or knee osteoarthritis in the MOA trial. DESIGN: Secondary analysis of a randomised controlled trial that compared the incremental effects of supervised MT and ET in addition to usual care in patients with osteoarthritis of the hip or knee. 206 participants enrolled in the MOA trial were analysed. The primary outcome measure was the WOMAC composite score after 1 year. RESULTS: Pain belief mediated the effect of MT (b: -10.7, 95 % CI: -22.3, -0.9), ET (b: -14.5 95%CI: -26.0, -4.4). Functional strength did not mediate the effect of MT, ET, or MT + ET. Mediation sensitivity analyses suggest findings are likely to change if small confounding between those mediators and WOMAC composite score is present. CONCLUSIONS: We identified possible mediators of MT and ET. Future confirmatory studies could be designed to assess the mechanisms through which manual therapy and exercise cause improvements in pain and function scores in patients with hip or knee osteoarthritis. | en_GB |
dc.description.sponsorship | Health Research Council of New Zealand | en_GB |
dc.description.sponsorship | National Institute for Health and Care Research (NIHR) | en_GB |
dc.identifier.citation | Vol. 6(1), article 100431 | en_GB |
dc.identifier.doi | https://doi.org/10.1016/j.ocarto.2023.100431 | |
dc.identifier.grantnumber | 18/111 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/135466 | |
dc.identifier | ORCID: 0000-0003-4349-7195 (Lamb, Sarah E) | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier / Osteoarthritis Research Society International (OARSI) | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38304412 | en_GB |
dc.rights | © 2024 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_GB |
dc.subject | Function | en_GB |
dc.subject | Mediation | en_GB |
dc.subject | Musculoskeletal diseases | en_GB |
dc.subject | Osteoarthritis | en_GB |
dc.subject | Pain | en_GB |
dc.subject | Randomized controlled trial | en_GB |
dc.title | Mediators of the effects of exercise and manual therapy for people with knee and hip osteoarthritis: A secondary, exploratory analysis of the MOA trial | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-03-04T13:04:46Z | |
dc.identifier.issn | 2665-9131 | |
exeter.article-number | 100431 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from Elsevier via the DOI in this record | en_GB |
dc.identifier.eissn | 2665-9131 | |
dc.identifier.journal | Osteoarthritis and Cartilage Open | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dcterms.dateAccepted | 2023-12-26 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-01-09 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-03-04T13:01:50Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-03-04T13:04:51Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-01-09 |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's licence is described as © 2024 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International (OARSI). This is an open access article under
the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).