Naturally occurring viruses of Drosophila reduce offspring number and lifespan
dc.contributor.author | Wallace, MA | |
dc.contributor.author | Obbard, DJ | |
dc.date.accessioned | 2024-05-28T08:56:41Z | |
dc.date.issued | 2024-05-15 | |
dc.date.updated | 2024-05-24T16:18:45Z | |
dc.description.abstract | Drosophila remains a pre-eminent insect model system for host-virus interaction, but the host range and fitness consequences of the drosophilid virome are poorly understood. Metagenomic studies have reported approximately 200 viruses associated with Drosophilidae, but few isolates are available to characterize the Drosophila immune response, and most characterization has relied on injection and systemic infection. Here, we use a more natural infection route to characterize the fitness effects of infection and to study a wider range of viruses. We exposed laboratory Drosophila melanogaster to 23 naturally occurring viruses from wild-collected drosophilids. We recorded transmission rates along with two components of female fitness: survival and the lifetime number of adult offspring produced. Nine different viruses transmitted during contact with laboratory D. melanogaster, although for the majority, rates of transmission were less than 20%. Five virus infections led to a significant decrease in lifespan (D. melanogaster Nora virus, D. immigrans Nora virus, Muthill virus, galbut virus and Prestney Burn virus), and three led to a reduction in the total number of offspring. Our findings demonstrate the utility of the Drosophila model for community-level studies of host-virus interactions, and suggest that viral infection could be a substantial fitness burden on wild flies. | en_GB |
dc.description.sponsorship | Natural Environment Research Council (NERC) | en_GB |
dc.format.extent | 20240518- | |
dc.format.medium | Print-Electronic | |
dc.identifier.citation | Vol. 291(2023), article 20240518 | en_GB |
dc.identifier.doi | https://doi.org/10.1098/rspb.2024.0518 | |
dc.identifier.grantnumber | NE/L002558/1 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/136038 | |
dc.identifier | ORCID: 0000-0001-5367-420X (Wallace, Megan A) | |
dc.language.iso | en | en_GB |
dc.publisher | The Royal Society | en_GB |
dc.relation.url | https://doi.org/10.6084/m9.figshare.22559866 | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38747703 | en_GB |
dc.rights | © 2024 The Authors. Open access. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. | en_GB |
dc.subject | Drosophila | en_GB |
dc.subject | fitness costs | en_GB |
dc.subject | insect viruses | en_GB |
dc.subject | virus transmission | en_GB |
dc.subject | viruses | en_GB |
dc.title | Naturally occurring viruses of Drosophila reduce offspring number and lifespan | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-05-28T08:56:41Z | |
dc.identifier.issn | 0962-8452 | |
exeter.place-of-publication | England | |
dc.description | This is the final version. Available on open access from the Royal Society via the DOI in this record | en_GB |
dc.description | Data accessibility: Raw data and code at https://doi.org/10.6084/m9.figshare.22559866 [65]. Raw reads from total RNA sequencing are in the sequence read archive under the Bioproject PRJNA1010185. Supplementary material is available online [66]. | en_GB |
dc.identifier.eissn | 1471-2954 | |
dc.identifier.journal | Proceedings of the Royal Society B: Biological Sciences | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2024-04-23 | |
dcterms.dateSubmitted | 2024-03-02 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-05-15 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-05-24T16:18:49Z | |
refterms.versionFCD | AM | |
refterms.dateFOA | 2024-05-28T08:56:45Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-05-15 | |
exeter.rights-retention-statement | Yes | |
exeter.rights-retention-statement | Yes |
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Except where otherwise noted, this item's licence is described as © 2024 The Authors. Open access. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.