Associations of between- and within-day patterns of physical activity accumulation with arterial stiffness and indices of microvascular health - Evidence from The Maastricht study
dc.contributor.author | Lear, R | |
dc.contributor.author | Metcalf, B | |
dc.contributor.author | Hillsdon, M | |
dc.contributor.author | Bond, B | |
dc.contributor.author | Koster, A | |
dc.contributor.author | Vandercappellen, E | |
dc.contributor.author | de Galan, B | |
dc.contributor.author | Berendschot, TTJM | |
dc.contributor.author | Houben, A | |
dc.contributor.author | Kooman, J | |
dc.contributor.author | Kroon, AA | |
dc.contributor.author | Bosma, H | |
dc.contributor.author | Eussen, SJPM | |
dc.contributor.author | Pulsford, R | |
dc.date.accessioned | 2024-06-07T12:08:21Z | |
dc.date.issued | 2024-05-16 | |
dc.date.updated | 2024-06-07T08:56:40Z | |
dc.description.abstract | While physical activity (PA) is understood to promote vascular health, little is known about whether the daily and weekly patterns of PA accumulation associate with vascular health. Accelerometer-derived (activPAL3) 6- or 7-day stepping was analyzed for 6430 participants in The Maastricht Study (50.4% women; 22.4% Type 2 diabetes mellitus (T2DM)). Multivariable regression models examined associations between stepping metrics (average step count, and time spent slower and faster paced stepping) with arterial stiffness (measured as carotid-femoral pulse wave velocity (cfPWV)), and several indices of microvascular health (heat-induced skin hyperemia, retinal vessel reactivity and diameter), adjusting for confounders and moderators. PA pattern metrics were added to the regression models to identify associations with vascular health beyond that of stepping metrics. Analyses were stratified by T2DM status if an interaction effect was present. Average step count and time spent faster paced stepping was associated with better vascular health, and the association was stronger in those with compared to those without T2DM. In fully adjusted models a higher step count inter-daily stability was associated with a higher (worse) cfPWV in those without T2DM (std β = 0.04, p = 0.007) and retinal venular diameter in the whole cohort (std β = 0.07, p = 0.002). A higher within-day variability in faster paced stepping was associated with a lower (worse) heat-induced skin hyperemia in those with T2DM (std β = -0.31, p = 0.008). Above and beyond PA volume, the daily and weekly patterns in which PA was accumulated were additionally associated with improved macro- and microvascular health, which may have implications for the prevention of vascular disease. | en_GB |
dc.description.sponsorship | European Regional Development Fund (ERDF) | en_GB |
dc.description.sponsorship | OP-Zuid | en_GB |
dc.description.sponsorship | Province of Limburg | en_GB |
dc.description.sponsorship | Dutch Ministry of Economic Affairs | en_GB |
dc.description.sponsorship | Stichting De Weijerhorst | en_GB |
dc.description.sponsorship | Pearl String Initiative Diabetes | en_GB |
dc.description.sponsorship | CARIM School for Cardiovascular Diseases | en_GB |
dc.description.sponsorship | CAPHRI Care and Public Health Research Institute | en_GB |
dc.description.sponsorship | NUTRIM School for Nutrition and Translational Research in Metabolism | en_GB |
dc.description.sponsorship | Stichting Annadal | en_GB |
dc.description.sponsorship | Health Foundation Limburg | en_GB |
dc.description.sponsorship | IMEDOS | en_GB |
dc.description.sponsorship | Janssen-Cilag B. V. | en_GB |
dc.description.sponsorship | Novo Nordisk Farma B. V. | en_GB |
dc.description.sponsorship | Sanofi-Aventis Netherlands B. V. | en_GB |
dc.identifier.citation | Vol. 34(5), article e14649 | en_GB |
dc.identifier.doi | https://doi.org/10.1111/sms.14649 | |
dc.identifier.grantnumber | 31O.041 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/136184 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/38757450 | en_GB |
dc.rights | © 2024 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | arterial stiffness | en_GB |
dc.subject | between‐day variability | en_GB |
dc.subject | inter‐daily stability | en_GB |
dc.subject | microvascular function | en_GB |
dc.subject | physical activity pattern | en_GB |
dc.subject | step count | en_GB |
dc.subject | vascular health | en_GB |
dc.subject | within‐day variability | en_GB |
dc.title | Associations of between- and within-day patterns of physical activity accumulation with arterial stiffness and indices of microvascular health - Evidence from The Maastricht study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-06-07T12:08:21Z | |
dc.identifier.issn | 0905-7188 | |
exeter.article-number | e14649 | |
exeter.place-of-publication | Denmark | |
dc.description | This is the final version. Available on open access from Wiley via the DOI in this record | en_GB |
dc.description | Data availability statement: The data of this study derived from The Maastricht Study, but restrictions apply to the availability of these data, which were used under license for the current study. Data are, however, available from the authors upon reasonable request and with permission of The Maastricht Study management team. | en_GB |
dc.identifier.eissn | 1600-0838 | |
dc.identifier.journal | Scandinavian Journal of Medicine & Science in Sports | en_GB |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_GB |
dcterms.dateAccepted | 2024-04-25 | |
rioxxterms.version | VoR | en_GB |
rioxxterms.licenseref.startdate | 2024-05-16 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-06-07T12:02:28Z | |
refterms.versionFCD | VoR | |
refterms.dateFOA | 2024-06-07T12:08:24Z | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-05-16 |
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Except where otherwise noted, this item's licence is described as © 2024 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.