dc.contributor.author | Brown, GD | |
dc.contributor.author | Ballou, ER | |
dc.contributor.author | Bates, S | |
dc.contributor.author | Bignell, EM | |
dc.contributor.author | Borman, AM | |
dc.contributor.author | Brand, AC | |
dc.contributor.author | Brown, AJP | |
dc.contributor.author | Coelho, C | |
dc.contributor.author | Cook, P | |
dc.contributor.author | Farrer, R | |
dc.contributor.author | Govender, NP | |
dc.contributor.author | Gow, NAR | |
dc.contributor.author | Hope, W | |
dc.contributor.author | Hoving, JC | |
dc.contributor.author | Dangarembizi, R | |
dc.contributor.author | Harrison, TS | |
dc.contributor.author | Johnson, EM | |
dc.contributor.author | Mukaremera, L | |
dc.contributor.author | Ramsdale, M | |
dc.contributor.author | Thornton, CR | |
dc.contributor.author | Usher, J | |
dc.contributor.author | Warris, A | |
dc.contributor.author | Wilson, D | |
dc.date.accessioned | 2024-06-26T14:07:32Z | |
dc.date.issued | 2024-06-25 | |
dc.date.updated | 2024-06-26T07:50:23Z | |
dc.description.abstract | Human fungal infections are a historically neglected area of disease research, yet they cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of these infections has increased considerably over the past decade, through major insights into both the host and pathogen factors that contribute to the phenotype and severity of these diseases. Recent studies are revealing multiple mechanisms by which fungi modify and manipulate the host, escape immune surveillance and generate complex comorbidities. Although the emergence of fungal strains that are less susceptible to antifungal drugs or that rapidly evolve drug resistance is posing new threats, greater understanding of immune mechanisms and host susceptibility factors is beginning to offer novel immunotherapeutic options for the future. In this Review, we provide a broad and comprehensive overview of the pathobiology of human fungal infections, focusing specifically on pathogens that can cause invasive life-threatening infections, highlighting recent discoveries from the pathogen, host and clinical perspectives. We conclude by discussing key future challenges including antifungal drug resistance, the emergence of new pathogens and new developments in modern medicine that are promoting susceptibility to infection. | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | Medical Research Council (MRC) | en_GB |
dc.description.sponsorship | UK Research and Innovation / Medical Research Council | en_GB |
dc.description.sponsorship | UK Research and Innovation / Medical Research Council | en_GB |
dc.description.sponsorship | UK Research and Innovation / Medical Research Council | en_GB |
dc.description.sponsorship | UK Research and Innovation / Medical Research Council | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | Biotechnology and Biological Sciences Research Council (BBSRC) | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | Centers for Disease Control and Prevention | en_GB |
dc.description.sponsorship | Royal Society | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | Lister Institute and an AMS Springboard Award | en_GB |
dc.identifier.citation | Awaiting citation and DOI | en_GB |
dc.identifier.doi | https://doi.org/10.1038/s41579-024-01062-w | |
dc.identifier.grantnumber | MR/N006364/2 | en_GB |
dc.identifier.grantnumber | MR/V033417/1 | en_GB |
dc.identifier.grantnumber | MR/M026663/2 | en_GB |
dc.identifier.grantnumber | MR/V005731/1 | en_GB |
dc.identifier.grantnumber | MR/X014010/1 | en_GB |
dc.identifier.grantnumber | MR/S001824/1 | en_GB |
dc.identifier.grantnumber | BB/V017004/1 | en_GB |
dc.identifier.grantnumber | BB/W009625/1 | en_GB |
dc.identifier.grantnumber | NIHR134342 | en_GB |
dc.identifier.grantnumber | NIHR303140 | en_GB |
dc.identifier.grantnumber | 1NU51CK000315-01-00 | en_GB |
dc.identifier.grantnumber | UF080611 | en_GB |
dc.identifier.grantnumber | 217163 | en_GB |
dc.identifier.grantnumber | 102705 | en_GB |
dc.identifier.grantnumber | 225303 | en_GB |
dc.identifier.grantnumber | 101873 | en_GB |
dc.identifier.grantnumber | 200208 | en_GB |
dc.identifier.grantnumber | 215599 | en_GB |
dc.identifier.grantnumber | 224323 | en_GB |
dc.identifier.grantnumber | WT2049 | en_GB |
dc.identifier.grantnumber | 209293 | en_GB |
dc.identifier.grantnumber | 218550/Z/19/Z | en_GB |
dc.identifier.grantnumber | 214317 | en_GB |
dc.identifier.grantnumber | 211241 | en_GB |
dc.identifier.grantnumber | 206412 | en_GB |
dc.identifier.grantnumber | WT105618MA | en_GB |
dc.identifier.grantnumber | SBF006/1024 (UK) | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/136451 | |
dc.identifier | ORCID: 0000-0003-0489-5705 (Bates, S) | |
dc.identifier | ScopusID: 7202010505 (Bates, S) | |
dc.identifier | ORCID: 0000-0001-7748-1920 (Bignell, EM) | |
dc.identifier | ScopusID: 6602285504 (Bignell, EM) | |
dc.identifier | ORCID: 0000-0001-8456-7458 (Farrer, R) | |
dc.identifier | ORCID: 0000-0001-6213-3130 (Thornton, CR) | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Research | en_GB |
dc.rights.embargoreason | Under embargo until 25 December 2024 in compliance with publisher policy | en_GB |
dc.rights | Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | en_GB |
dc.subject | Fungal genomics | en_GB |
dc.subject | Fungal host response | en_GB |
dc.subject | Fungal immune evasion | en_GB |
dc.subject | Fungal pathogenesis | en_GB |
dc.title | The pathobiology of human fungal infections | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2024-06-26T14:07:32Z | |
dc.identifier.issn | 1740-1526 | |
dc.description | This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this record | en_GB |
dc.identifier.eissn | 1740-1534 | |
dc.identifier.journal | Nature Reviews Microbiology | en_GB |
dc.relation.ispartof | Nature Reviews Microbiology | |
dc.rights.uri | http://www.rioxx.net/licenses/all-rights-reserved | en_GB |
dcterms.dateAccepted | 2024-05-14 | |
dcterms.dateSubmitted | 2023-11-07 | |
rioxxterms.version | AM | en_GB |
rioxxterms.licenseref.startdate | 2024-06-25 | |
rioxxterms.type | Journal Article/Review | en_GB |
refterms.dateFCD | 2024-06-26T07:50:25Z | |
refterms.versionFCD | AM | |
refterms.panel | A | en_GB |
refterms.dateFirstOnline | 2024-06-25 | |
exeter.rights-retention-statement | Yes | |