Show simple item record

Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata?

dc.contributor.authorBedekovic, T
dc.contributor.authorUsher, J
dc.date.accessioned2024-09-12T12:13:43Z
dc.date.issued2023-04-22
dc.date.updated2024-09-12T10:18:58Z
dc.description.abstractPURPOSE OF REVIEW: Human fungal pathogens are rapidly increasing in incidence and readily able to evade the host immune responses. Our ability to study the genetic behind this has been limited due to the apparent lack of a sexual cycle and forward genetic tools. In this review, we discuss the evolution of mating, meiosis, and pathogenesis and if these processes are advantageous to pathogens. RECENT FINDINGS: This review summarises what is currently known about the sexual cycles of two important human fungal pathogens, Candida albicans and Candida glabrata. This includes the identification of parasexual cycle in C. albicans and the observed low levels of recombination in C. glabrata populations. SUMMARY: In this review, we present what is currently known about the mating types and mating/sexual cycles of two clinically important human fungal pathogens, Candida albicans and Candida glabrata. We discuss the evolution of meiosis using the knowledge that has been amassed from the decades of studying Saccharomyces cerevisiae and how this can be applied to fungal pathogens. We further discuss how the evolution of pathogenesis has played a role in influencing mating processes in human fungal pathogens and compare sexual cycles between C. albicans and C. glabrata, highlighting knowledge gaps and suggesting how these two fungi have evolved distinct mating niches to allow the development of disease in a human host.en_GB
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC)en_GB
dc.format.extent47-54
dc.identifier.citationVol. 10(2), pp. 47-54en_GB
dc.identifier.doihttps://doi.org/10.1007/s40588-023-00192-8
dc.identifier.grantnumberBB/W009625/1en_GB
dc.identifier.urihttp://hdl.handle.net/10871/137420
dc.identifierORCID: 0000-0002-0604-291X (Usher, Jane)
dc.language.isoenen_GB
dc.publisherSpringeren_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/37151577en_GB
dc.rights© The Author(s) 2023. Open access. This article is licensed under a Creative Commons Attri bution 4.0 International License, which permits use, sharing, adapta tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/en_GB
dc.subjectCandida albicansen_GB
dc.subjectCandida glabrataen_GB
dc.subjectEvolutionen_GB
dc.subjectMatingen_GB
dc.subjectPathogenesisen_GB
dc.titleIs There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata?en_GB
dc.typeArticleen_GB
dc.date.available2024-09-12T12:13:43Z
dc.identifier.issn2196-5471
exeter.place-of-publicationSwitzerland
dc.descriptionThis is the final version. Available on open access from Springer via the DOI in this recorden_GB
dc.identifier.eissn2196-5471
dc.identifier.journalCurrent Clinical Microbiology Reportsen_GB
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_GB
dcterms.dateAccepted2023-03-30
rioxxterms.versionVoRen_GB
rioxxterms.licenseref.startdate2023-04-22
rioxxterms.typeJournal Article/Reviewen_GB
refterms.dateFCD2024-09-12T12:11:08Z
refterms.versionFCDVoR
refterms.dateFOA2024-09-12T12:14:17Z
refterms.panelAen_GB
refterms.dateFirstOnline2023-04-22


Files in this item

Name:
Is There a Relationship Between ...
Size:
993.4Kb
Format:
PDF
Description:
Is There a Relationship Between ...
View/Open

This item appears in the following Collection(s)

Show simple item record

© The Author(s) 2023. Open access. This article is licensed under a Creative Commons Attri bution 4.0 International License, which permits use, sharing, adapta tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's licence is described as © The Author(s) 2023. Open access. This article is licensed under a Creative Commons Attri bution 4.0 International License, which permits use, sharing, adapta tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/