Programmed cell death in pathogenic fungi.
Biochimica et Biophysica Acta
Greater understanding of programmed cell death (PCD) responses in pathogenic fungi may offer a chance of exploiting the fungal molecular death machinery to control fungal infections. Clearly identifiable differences between the death machineries of pathogens and their hosts, make this a feasible target. Evidence for PCD in a range of pathogenic fungi is discussed alongside an evaluation of the capacity of existing antifungal agents to promote apoptosis and other forms of cell death. Information about death related signalling pathways that have been examined in pathogens as diverse as Candida albicans, Aspergillus fumigatus, Magnaporthe grisea and Colletotrichum trifolii are discussed.
addresses: School of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter, UK. M.Ramsdale@exeter.ac.uk
types: Journal Article; Research Support, Non-U.S. Gov't; Review
Copyright © 2008 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta, 2008, Vol. 1783, Issue 7, pp. 1369 – 1380 DOI: 10.1016/j.bbamcr.2008.01.021
Biochimica et Biophysica Acta, 2008, Vol. 1783, Issue 7, pp. 1369 - 1380
Place of publication