dc.contributor.author | Eggleton, P | |
dc.contributor.author | Ukoumunne, Obioha C. | |
dc.contributor.author | Cottrell, I | |
dc.contributor.author | Khan, A | |
dc.contributor.author | Maqsood, S | |
dc.contributor.author | Thornes, J | |
dc.contributor.author | Perry, E | |
dc.contributor.author | Isenberg, D | |
dc.date.accessioned | 2014-06-06T13:23:41Z | |
dc.date.issued | 2014-04-22 | |
dc.description.abstract | Objectives: To evaluate the diagnostic accuracy of C1q autoantibodies in identifying lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). Data Sources and methods: Citation indexes were searched and 370 articles published from 1977 to 2013 were evaluated. The 31 selected studies included in the meta-analysis were cross-sectional in design. Among the 31 studies, 28 compared anti-C1q antibodies in 2769 SLE patients including those with (n = 1442) and without a history of LN (n = 1327). Nine studies examined anti-C1q in 517 SLE patients with active (n = 249) and inactive LN (n = 268). Hierarchical summary receiver operating characteristic (HSROC) random effects models were fitted to pool estimates of accuracy across the studies. Results: Anti-C1q antibodies discriminated between patients with and without a history of LN, with a median specificity of 73.5%. The HSROC model estimated the corresponding sensitivity to be 70.4%. A hypothetical patient with a 55% prior probability of having a history of LN as opposed to no history (the median prevalence across 28 eligible studies) would have a post-test probability of 76.4% following a positive test result (positive predictive value) or 33.0% following a negative test result (negative predictive value). For differentiating active from inactive LN the median specificity of anti-C1q antibodies was 80%, with a corresponding estimated sensitivity value 75.7% based on the HSROC model. A hypothetical patient with a 56% prior probability of active as opposed to inactive LN (the median prevalence across the 9 eligible studies) would have a post-test probability of 82.8% following a positive test result or 27.9% following a negative test result. Conclusions: Although C1q antibodies are associated with lupus nephritis the post-test probabilities are not sufficiently convincing to provide reasonable certainty of the presence or absence of history of disease/active disease. | en_GB |
dc.description.sponsorship | Arthritis Research UK | en_GB |
dc.description.sponsorship | Peninsula Collaboration for Leadership in Applied
Health Research and Care (CLAHRC) | en_GB |
dc.description.sponsorship | National Health Service
South West, funded by the National Institute for Health Research, UK | en_GB |
dc.identifier.citation | Journal of clinical and cellular immunology (2014) Vol. 5, Issue 2 | en_GB |
dc.identifier.doi | 10.4172/2155-9899.1000210 | |
dc.identifier.grantnumber | 19894 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/14957 | |
dc.language.iso | en | en_GB |
dc.publisher | OMICS Publishing Group | en_GB |
dc.relation.url | http://omicsonline.org/clinical-cellular-immunology.php | en_GB |
dc.rights | © 2014 Eggleton P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.subject | Autoantibody | en_GB |
dc.subject | Biopsy | en_GB |
dc.subject | Diagnosis | en_GB |
dc.subject | ELISA | en_GB |
dc.subject | Hierarchical summary receiver operating characteristic | en_GB |
dc.subject | C1q | en_GB |
dc.subject | systemic lupus erythematosus | en_GB |
dc.title | Autoantibodies against C1q as a diagnostic measure of lupus nephritis:systematic review and meta-analysis | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2014-06-06T13:23:41Z | |
dc.contributor.editor | Su, K | |
dc.description | This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record. | en_GB |
dc.identifier.journal | Journal of clinical and cellular immunology | en_GB |