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Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia

dc.contributor.authorSteele, AM
dc.contributor.authorShields, BM
dc.contributor.authorWensley, KJ
dc.contributor.authorColclough, K
dc.contributor.authorEllard, Sian
dc.contributor.authorHattersley, Andrew T.
dc.date.accessioned2014-08-26T14:00:43Z
dc.date.issued2014-01-15
dc.description.abstractGlycemic targets in diabetes have been developed to minimize complication risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting hyperglycemia from birth, resulting in an elevated glycated hemoglobin (HbA1c) level that mimics recommended levels for type 1 and type 2 diabetes.en_GB
dc.description.sponsorshipDiabetes UKen_GB
dc.description.sponsorshipNational Institute for Health Research (NIHR)en_GB
dc.description.sponsorshipEuropean Community’s Seventh Framework Programmeen_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.identifier.citationJAMA, 2014, Vol. 311, Issue 3, pp. 279 - 286en_GB
dc.identifier.doi10.1001/jama.2013.283980
dc.identifier.grantnumberBDA:RD07/0003473en_GB
dc.identifier.grantnumberCEED3 223211en_GB
dc.identifier.urihttp://hdl.handle.net/10871/15378
dc.language.isoenen_GB
dc.publisherAmerican Medical Associationen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24430320en_GB
dc.rightsCopyright 2014 American Medical Associationen_GB
dc.subjectAdulten_GB
dc.subjectCase-Control Studiesen_GB
dc.subjectCross-Sectional Studiesen_GB
dc.subjectDiabetes Complicationsen_GB
dc.subjectDiabetes Mellitus, Type 2en_GB
dc.subjectFemaleen_GB
dc.subjectGlucokinaseen_GB
dc.subjectHemoglobin A, Glycosylateden_GB
dc.subjectHumansen_GB
dc.subjectHyperglycemiaen_GB
dc.subjectMaleen_GB
dc.subjectMiddle Ageden_GB
dc.subjectMutationen_GB
dc.subjectPrevalenceen_GB
dc.subjectSeverity of Illness Indexen_GB
dc.subjectTime Factorsen_GB
dc.titlePrevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemiaen_GB
dc.typeArticleen_GB
dc.date.available2014-08-26T14:00:43Z
dc.identifier.issn0098-7484
exeter.place-of-publicationUnited States
dc.descriptionThis is the author’s version of a work that was accepted for publication in JAMA. Please cite the published version which can be accessed via the DOI in this record.en_GB
dc.identifier.journalJournal of the Americal Medical Association (JAMA)en_GB


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