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dc.contributor.authorBates, S
dc.contributor.authorHall, RA
dc.contributor.authorCheetham, Jill
dc.contributor.authorNetea, MG
dc.contributor.authorMacCallum, DM
dc.contributor.authorBrown, AJ
dc.contributor.authorOdds, FC
dc.contributor.authorGow, NA
dc.date.accessioned2014-08-29T10:01:10Z
dc.date.issued2013-07-26
dc.description.abstractThe Candida albicans cell wall is the first point of contact with the host, and its outer surface is heavily enriched in mannoproteins modified through the addition of N- and O-mannan. Previous work, using mutants with gross defects in glycosylation, has clearly identified the importance of mannan in the host-pathogen interaction, immune recognition and virulence. Here we report the first analysis of the MNN1 gene family, which contains six members predicted to act as α-1,3 mannosyltransferases in the terminal stages of glycosylation.en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipBBSRCen_GB
dc.description.sponsorshipBBSRC SABR (CRISP)en_GB
dc.identifier.citationVol. 6, article 294en_GB
dc.identifier.doi10.1186/1756-0500-6-294
dc.identifier.grantnumber080088en_GB
dc.identifier.grantnumberFP7-2007-2013en_GB
dc.identifier.grantnumberHEALTH-F2- 2010-260338–ALLFUNen_GB
dc.identifier.grantnumberBB/F009232/1en_GB
dc.identifier.other1756-0500-6-294
dc.identifier.urihttp://hdl.handle.net/10871/15396
dc.language.isoenen_GB
dc.publisherBioMed Centralen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23886038en_GB
dc.subjectCandida albicansen_GB
dc.subjectCell Wallen_GB
dc.subjectFungal Proteinsen_GB
dc.subjectGenes, Fungalen_GB
dc.subjectGlycosylationen_GB
dc.subjectMultigene Familyen_GB
dc.subjectPhylogenyen_GB
dc.subjectVirulenceen_GB
dc.titleRole of the Candida albicans MNN1 gene family in cell wall structure and virulenceen_GB
dc.typeArticleen_GB
dc.date.available2014-08-29T10:01:10Z
exeter.place-of-publicationEngland
dc.description© 2013 Bates et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_GB
dc.identifier.journalBMC Research Notesen_GB


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