dc.contributor.author | Bates, S | |
dc.contributor.author | Hall, RA | |
dc.contributor.author | Cheetham, Jill | |
dc.contributor.author | Netea, MG | |
dc.contributor.author | MacCallum, DM | |
dc.contributor.author | Brown, AJ | |
dc.contributor.author | Odds, FC | |
dc.contributor.author | Gow, NA | |
dc.date.accessioned | 2014-08-29T10:01:10Z | |
dc.date.issued | 2013-07-26 | |
dc.description.abstract | The Candida albicans cell wall is the first point of contact with the host, and its outer surface is heavily enriched in mannoproteins modified through the addition of N- and O-mannan. Previous work, using mutants with gross defects in glycosylation, has clearly identified the importance of mannan in the host-pathogen interaction, immune recognition and virulence. Here we report the first analysis of the MNN1 gene family, which contains six members predicted to act as α-1,3 mannosyltransferases in the terminal stages of glycosylation. | en_GB |
dc.description.sponsorship | Wellcome Trust | en_GB |
dc.description.sponsorship | BBSRC | en_GB |
dc.description.sponsorship | BBSRC SABR (CRISP) | en_GB |
dc.identifier.citation | Vol. 6, article 294 | en_GB |
dc.identifier.doi | 10.1186/1756-0500-6-294 | |
dc.identifier.grantnumber | 080088 | en_GB |
dc.identifier.grantnumber | FP7-2007-2013 | en_GB |
dc.identifier.grantnumber | HEALTH-F2- 2010-260338–ALLFUN | en_GB |
dc.identifier.grantnumber | BB/F009232/1 | en_GB |
dc.identifier.other | 1756-0500-6-294 | |
dc.identifier.uri | http://hdl.handle.net/10871/15396 | |
dc.language.iso | en | en_GB |
dc.publisher | BioMed Central | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/23886038 | en_GB |
dc.subject | Candida albicans | en_GB |
dc.subject | Cell Wall | en_GB |
dc.subject | Fungal Proteins | en_GB |
dc.subject | Genes, Fungal | en_GB |
dc.subject | Glycosylation | en_GB |
dc.subject | Multigene Family | en_GB |
dc.subject | Phylogeny | en_GB |
dc.subject | Virulence | en_GB |
dc.title | Role of the Candida albicans MNN1 gene family in cell wall structure and virulence | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2014-08-29T10:01:10Z | |
exeter.place-of-publication | England | |
dc.description | © 2013 Bates et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.identifier.journal | BMC Research Notes | en_GB |