Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor
Green, Stephen J.
Winlove, C. Peter
Winyard, Paul G.
American Chemical Society
© 2014 American Chemical Society
Reason for embargo
Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold-gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.
This is the peer reviewed version of the article, which has been published in final form at doi: 10.1021/ac501321e.
Analytical Chemistry, 2014, Vol. 86, Issue 14, pp. 6748 - 6752
Place of publication