Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor
Hammond, JL; Gross, AJ; Estrela, P; et al.Iniesta, J; Green, Stephen J.; Winlove, C. Peter; Winyard, Paul G.; Benjamin, N; Marken, F
Date: 15 July 2014
Journal
Analytical Chemistry
Publisher
American Chemical Society
Publisher DOI
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Abstract
Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold-gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but ...
Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold-gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.
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