Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?
Morgan, Noel G.
Richardson, Sarah J.
Trends in Endocrinology and Metabolism
Considerable evidence implies that an enteroviral infection may accelerate or precipitate type 1 diabetes (T1D) in some individuals. However, causality is not proven. We present and critically assess evidence suggesting that islet β cells can become infected with enterovirus, and argue that this may result in one of several consequences. Occasionally, a fully lytic infection may arise and this culminates in fulminant diabetes. Alternatively, an atypical persistent infection develops which can be either benign or promote islet autoimmunity. We propose a model in which the 'strength' of the β cell response to the establishment of a persistent enteroviral infection determines the final disease outcome.
European Commission 7th Framework Programme PEVNET [FP7/2007-2013]
Diabetes Research Wellness Foundation Non-Clinical Research Fellowship
Juvenile Diabetes Research Foundation (JDRF) Career Development Award
Network for Pancreatic Organ Donors with Diabetes (nPOD)
Vol. 25 (12), pp. 611 - 619
Place of publication