Production and Cross-sectional Characterization of Aligned Co-electrospun Hollow Microfibrous Bulk Assemblies
Parker, Geoff J.M.
Eichhorn, Stephen J.
Hubbard Cristinacce, Penny L.
Copyright © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
The development of co-electrospun (co-ES) hollow microfibrous assemblies of an appreciable thickness is critical for many practical applications, including filtration membranes and tissue-mimicking scaffolds. In this study, thick uniaxially aligned hollow microfibrous assemblies forming fiber bundles and strips were prepared by co-ES of polycaprolactone (PCL) and polyethylene oxide (PEO) as shell and core, respectively. Hollow microfiber bundles were deposited on a fixed rotating disc, which resulted in non-controllable cross-sectional shape on a macroscopic scale. In comparison, fiber strips were produced with tuneable thickness and width by additionally employing an x-y translation stage in co-ES. Scanning electron microscopy (SEM) images of cross-sections of fiber assemblies were analysed to investigate the effects of production time (from 0.5 h to 12 h), core flow rate (from 0.8 mL/h to 2.0 mL/h) and/or translation speed (from 0.2 mm/s to 5 mm/s) on the pores and porosity. We observed significant changes in pore size and shape with core flow rate but the influence of production time varied; five strips produced under the same condition had reasonably good size and porosity reproducibility; pore sizes didn’t vary significantly from strip bottom to surface, although the porosity gradually decreased and then returned to the initial level.
Seventh Framework Program for Research of the European Commission - Future and Emerging Technologies (FET) Program
Engineering and Physical Sciences Research Council (EPSRC)
Cancer Research UK
Copyright © 2015 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Materials Characterization. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Characterization (2015), DOI: 10.1016/j.matchar.2015.09.010
Open Access article funded by Cancer Research UK
Vol. 109 pp. 25-35