Show simple item record

dc.contributor.authorSchrader, M
dc.contributor.authorCostello, J
dc.contributor.authorGodinho, Luis F.
dc.contributor.authorAzadi, A
dc.contributor.authorIslinger, M
dc.date.accessioned2015-09-28T08:33:36Z
dc.date.issued2015-09-26
dc.description.abstractIn mammals, peroxisomes perform crucial functions in cellular metabolism, signalling and viral defense which are essential to the health and viability of the organism. In order to achieve this functional versatility peroxisomes dynamically respond to molecular cues triggered by changes in the cellular environment. Such changes elicit a corresponding response in peroxisomes, which manifests itself as a change in peroxisome number, altered enzyme levels and adaptations to the peroxisomal structure. In mammals the generation of new peroxisomes is a complex process which has clear analogies to mitochondria, with both sharing the same division machinery and undergoing a similar division process. How the regulation of this division process is integrated into the cell's response to different stimuli, the signalling pathways and factors involved, remains somewhat unclear. Here, we discuss the mechanism of peroxisomal fission, the contributions of the various division factors and examine the potential impact of post-translational modifications, such as phosphorylation, on the proliferation process. We also summarize the signalling process and highlight the most recent data linking signalling pathways with peroxisome proliferation.en_GB
dc.description.sponsorshipBBSRCen_GB
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT)en_GB
dc.description.sponsorshipFP-7-PEOPLE-2012-Marie Curie-ITN 316723 PERFUMEen_GB
dc.identifier.citationAvailable online 26 September 2015en_GB
dc.identifier.doi10.1016/j.bbamcr.2015.09.024
dc.identifier.grantnumberBB/K006231/1en_GB
dc.identifier.grantnumberSFRH/BPD/90084/2012en_GB
dc.identifier.urihttp://hdl.handle.net/10871/18323
dc.language.isoenen_GB
dc.publisherElsevieren_GB
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0167488915003365en_GB
dc.rights.embargoreasonPublisher's policyen_GB
dc.rightsCopyright © 2015 Published by Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/en_GB
dc.subjectperoxisome proliferationen_GB
dc.subjectorganelle dynamicsen_GB
dc.subjectDLP1/Drp1en_GB
dc.subjectFis1en_GB
dc.subjectMffen_GB
dc.subjectPex11en_GB
dc.subjectPPARen_GB
dc.titleProliferation and fission of peroxisomes - an updateen_GB
dc.typeArticleen_GB
dc.identifier.issn0006-3002
dc.descriptionReviewen_GB
dc.identifier.journalBBA - Biochimica et Biophysica Acta: Molecular Cell Researchen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record