The potential role of the proteases cathepsin D and cathepsin L in the progression and metastasis of epithelial ovarian cancer.
Gotowski, Nicholas J.
Whatmore, Jacqueline L.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecologic malignancies and has a poor prognosis due to relatively unspecific early symptoms, and thus often advanced stage, metastasized cancer at presentation. Metastasis of EOC occurs primarily through the transcoelomic route whereby exfoliated tumor cells disseminate within the abdominal cavity, particularly to the omentum. Primary and metastatic tumor growth requires a pool of proangiogenic factors in the microenvironment which propagate new vasculature in the growing cancer. Recent evidence suggests that proangiogenic factors other than the widely known, potent angiogenic factor vascular endothelial growth factor may mediate growth and metastasis of ovarian cancer. In this review we examine the role of some of these alternative factors, specifically cathepsin D and cathepsin L.
This article belongs to the Special Issue: Signal Transduction Pathways in Gynecologic Malignancies
Version of record available via the publisher at: doi:10.3390/biom5043260
© 1996-2015 MDPI AG (Basel, Switzerland).
Vol. 5, pp. 3260 - 3279
Place of publication