Show simple item record

dc.contributor.authorDevall, Matthew
dc.contributor.authorMill, J
dc.contributor.authorLunnon, Katie
dc.date.accessioned2016-02-05T13:41:29Z
dc.date.issued2014
dc.description.abstractConsiderable evidence suggests that mitochondrial dysfunction occurs early in Alzheimer's disease, both in affected brain regions and in leukocytes, potentially precipitating neurodegeneration through increased oxidative stress. Epigenetic processes are emerging as a dynamic mechanism through which environmental signals may contribute to cellular changes, leading to neuropathology and disease. Until recently, little attention was given to the mitochondrial epigenome itself, as preliminary studies indicated an absence of DNA modifications. However, recent research has demonstrated that epigenetic changes to the mitochondrial genome do occur, potentially playing an important role in several disorders characterized by mitochondrial dysfunction. This review explores the potential role of mitochondrial epigenetic dysfunction in Alzheimer's disease etiology and discusses some technical issues pertinent to the study of these processes.en_GB
dc.description.sponsorshipAlzheimer’s Research UKen_GB
dc.description.sponsorshipNIHen_GB
dc.identifier.citationVol. 6 (6), pp. 665 - 675en_GB
dc.identifier.doi10.2217/epi.14.50
dc.identifier.grantnumberAG036039en_GB
dc.identifier.urihttp://hdl.handle.net/10871/19628
dc.language.isoenen_GB
dc.publisherFuture Medicineen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25531259en_GB
dc.subject5-hydroxymethylcytosineen_GB
dc.subject5-methylcytosine:en_GB
dc.subjectAlzheimer's diseaseen_GB
dc.subjectDNA methylationen_GB
dc.subjectdementiaen_GB
dc.subjectepigeneticsen_GB
dc.subjectheteroplasmyen_GB
dc.subjectmitochondriaen_GB
dc.subjectAlzheimer Diseaseen_GB
dc.subjectBrainen_GB
dc.subjectDNA Methylationen_GB
dc.subjectEpigenesis, Geneticen_GB
dc.subjectGenome, Mitochondrialen_GB
dc.subjectHumansen_GB
dc.subjectMitochondriaen_GB
dc.subjectOxidative Stressen_GB
dc.titleThe mitochondrial epigenome: a role in Alzheimer's disease?en_GB
dc.typeArticleen_GB
dc.date.available2016-02-05T13:41:29Z
dc.identifier.issn1750-1911
exeter.place-of-publicationEngland
dc.identifier.eissn1750-192X
dc.identifier.journalEpigenomicsen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record