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dc.contributor.authorHarries, LW
dc.date.accessioned2016-02-11T15:45:26Z
dc.date.issued2014-08-20
dc.description.abstractHuman ageing is a complex and integrated gradual deterioration of cellular processes. There are nine major hallmarks of ageing, that include changes in DNA repair and DNA damage response, telomere shortening, changes in control over the expression and regulation of genes brought about by epigenetic and mRNA processing changes, loss of protein homeostasis, altered nutrient signaling, mitochondrial dysfunction, stem cell exhaustion, premature cellular senescence and altered intracellular communication. Like practically all other cellular processes, genes associated in features of ageing are regulated by miRNAs. In this review, I will outline each of the features of ageing, together with examples of specific miRNAs that have been demonstrated to be involved in each one. This will demonstrate the interconnected nature of the regulation of transcripts involved in human ageing, and the role of miRNAs in this process. Definition of the factors involved in degeneration of organismal, tissue and cellular homeostasis may provide biomarkers for healthy ageing and increase understanding of the processes that underpin the ageing process itself.en_GB
dc.description.sponsorshipWellcome Trusten_GB
dc.description.sponsorshipMRCen_GB
dc.identifier.citationGenes, 2014, Vol. 5 (3), pp. 656 - 670en_GB
dc.identifier.doi10.3390/genes5030656
dc.identifier.urihttp://hdl.handle.net/10871/19738
dc.language.isoenen_GB
dc.publisherMDPIen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25140888en_GB
dc.rightsCopyright © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).en_GB
dc.titleMicroRNAs as Mediators of the Ageing Process.en_GB
dc.typeArticleen_GB
dc.date.available2016-02-11T15:45:26Z
dc.identifier.issn2073-4425
exeter.place-of-publicationSwitzerland
dc.descriptionPublished onlineen_GB
dc.descriptionReviewen_GB
dc.identifier.journalGenesen_GB


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