Show simple item record

dc.contributor.authorLourida, I
dc.contributor.authorThompson-Coon, Jo
dc.contributor.authorDickens, Chris
dc.contributor.authorSoni, Maya
dc.contributor.authorKuźma, Elżbieta
dc.contributor.authorKos, Katarina
dc.contributor.authorLlewellyn, DJ
dc.date.accessioned2016-02-15T13:38:50Z
dc.date.issued2015-05-26
dc.description.abstractBACKGROUND: Metabolic factors are increasingly recognized to play an important role in the pathogenesis of Alzheimer's disease and dementia. Abnormal parathyroid hormone (PTH) levels play a role in neuronal calcium dysregulation, hypoperfusion and disrupted neuronal signaling. Some studies support a significant link between PTH levels and dementia whereas others do not. METHODS: We conducted a systematic review through January 2014 to evaluate the association between PTH and parathyroid conditions, cognitive function and dementia. Eleven electronic databases and citation indexes were searched including Medline, Embase and the Cochrane Library. Hand searches of selected journals, reference lists of primary studies and reviews were also conducted along with websites of key organizations. Two reviewers independently screened titles and abstracts of identified studies. Data extraction and study quality were performed by one and checked by a second reviewer using predefined criteria. A narrative synthesis was performed due to the heterogeneity of included studies. RESULTS: The twenty-seven studies identified were of low and moderate quality, and challenging to synthesize due to inadequate reporting. Findings from six observational studies were mixed but suggest a link between higher serum PTH levels and increased odds of poor cognition or dementia. Two case-control studies of hypoparathyroidism provide limited evidence for a link with poorer cognitive function. Thirteen pre-post surgery studies for primary hyperparathyroidism show mixed evidence for improvements in memory though limited agreement in other cognitive domains. There was some degree of cognitive impairment and improvement postoperatively in observational studies of secondary hyperparathyroidism but no evident pattern of associations with specific cognitive domains. CONCLUSIONS: Mixed evidence offers weak support for a link between PTH, cognition and dementia due to the paucity of high quality research in this area.en_GB
dc.description.sponsorshipNIHR PenCLAHRCen_GB
dc.description.sponsorshipAlzheimer’s Associationen_GB
dc.description.sponsorshipRosetrees Trusten_GB
dc.description.sponsorshipMary Kinross Charitable Trusten_GB
dc.description.sponsorshipJames Tudor Foundationen_GB
dc.description.sponsorshipHalpin Trusten_GB
dc.description.sponsorshipNorman Family Charitable Trusten_GB
dc.identifier.citationVol. 10, Iss. 5, article e0127574en_GB
dc.identifier.doi10.1371/journal.pone.0127574
dc.identifier.grantnumberNIRG-11-200737en_GB
dc.identifier.otherPONE-D-15-05460
dc.identifier.urihttp://hdl.handle.net/10871/19849
dc.language.isoenen_GB
dc.publisherPublic Library of Scienceen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26010883en_GB
dc.rightsCopyright © 2015 Lourida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_GB
dc.titleParathyroid hormone, cognitive function and dementia: a systematic reviewen_GB
dc.typeArticleen_GB
dc.date.available2016-02-15T13:38:50Z
dc.identifier.issn1932-6203
exeter.place-of-publicationUnited States
dc.identifier.journalPLoS Oneen_GB


Files in this item

This item appears in the following Collection(s)

Show simple item record