dc.contributor.author | Kuźma, Elżbieta | |
dc.contributor.author | Llewellyn, DJ | |
dc.contributor.author | Langa, KM | |
dc.contributor.author | Wallace, Robert B. | |
dc.contributor.author | Lang, IA | |
dc.date.accessioned | 2016-02-19T10:24:36Z | |
dc.date.issued | 2014-10 | |
dc.description.abstract | OBJECTIVE: To assess the effects of a history of alcohol use disorders (AUDs) on risk of severe cognitive and memory impairment in later life. METHODS: We studied the association between history of AUDs and the onset of severe cognitive and memory impairment in 6,542 middle-aged adults born 1931 through 1941 who participated in the Health and Retirement Study, a prospective nationally representative U.S. cohort. Participants were assessed at 1992 baseline and follow-up cognitive assessments were conducted biannually from 1996 through 2010. History of AUDs was identified using the three-item modified CAGE questionnaire. Cognitive outcomes were assessed using the 35-item modified Telephone Interview for Cognitive Status at last follow-up with incident severe cognitive impairment defined as a score ≤ 8, and incident severe memory impairment defined as a score ≤ 1 on a 20-item memory subscale. RESULTS: During up to 19 years of follow-up (mean: 16.7 years, standard deviation: 3.0, range: 3.5-19.1 years), 90 participants experienced severe cognitive impairment and 74 participants experienced severe memory impairment. History of AUDs more than doubled the odds of severe memory impairment (odds ratio [OR] = 2.21, 95% confidence interval [CI] = 1.27-3.85, t = 2.88, df = 52, p = 0.01). The association with severe cognitive impairment was statistically non-significant but in the same direction (OR = 1.80, 95% CI = 0.97-3.33, t = 1.92, df = 52, p = 0.06). CONCLUSION: Middle-aged adults with a history of AUDs have increased odds of developing severe memory impairment later in life. These results reinforce the need to consider the relationship between alcohol consumption and cognition from a multifactorial lifespan perspective. | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula | en_GB |
dc.description.sponsorship | National Institute for Health Research Knowledge Mobilisation Research Fellowship | en_GB |
dc.description.sponsorship | National Institute for Health Research | en_GB |
dc.description.sponsorship | Mary Kinross Charitable Trust | en_GB |
dc.description.sponsorship | Alzheimer Association | en_GB |
dc.description.sponsorship | Norman Family Charitable Trust | en_GB |
dc.description.sponsorship | James Tudor Foundation | en_GB |
dc.description.sponsorship | Halpin Trust | en_GB |
dc.identifier.citation | Vol. 22 (10), pp. 1047 - 1054 | en_GB |
dc.identifier.doi | 10.1016/j.jagp.2014.06.001 | |
dc.identifier.grantnumber | NIRG-11-200737 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10871/19959 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25091517 | en_GB |
dc.rights | Open Access funded by Department of Health UK. Under a Creative Commons license: http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_GB |
dc.subject | Alcohol use disorders | en_GB |
dc.subject | CAGE | en_GB |
dc.subject | cognitive impairment | en_GB |
dc.subject | memory impairment | en_GB |
dc.subject | Alcohol-Related Disorders | en_GB |
dc.subject | Cognition Disorders | en_GB |
dc.subject | Diagnosis, Dual (Psychiatry) | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Incidence | en_GB |
dc.subject | Male | en_GB |
dc.subject | Memory Disorders | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | Prospective Studies | en_GB |
dc.subject | Risk Factors | en_GB |
dc.subject | United States | en_GB |
dc.title | History of alcohol use disorders and risk of severe cognitive impairment: a 19-year prospective cohort study | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-02-19T10:24:36Z | |
dc.identifier.issn | 1064-7481 | |
pubs.declined | 2016-02-23T20:15:17.569+0000 | |
pubs.deleted | 2016-02-23T20:15:17.624+0000 | |
exeter.place-of-publication | England | |
dc.identifier.eissn | 1545-7214 | |
dc.identifier.journal | American Journal of Geriatric Psychiatry | en_GB |