dc.contributor.author | Littlejohns, Thomas J. | |
dc.contributor.author | Kos, Katarina | |
dc.contributor.author | Henley, William E. | |
dc.contributor.author | Cherubini, Antonio | |
dc.contributor.author | Ferrucci, L | |
dc.contributor.author | Lang, IA | |
dc.contributor.author | Langa, KM | |
dc.contributor.author | Melzer, D | |
dc.contributor.author | Llewellyn, DJ | |
dc.date.accessioned | 2016-02-19T14:40:59Z | |
dc.date.issued | 2015-01-01 | |
dc.description.abstract | Background: US studies suggest that leptin, a fat-derived hormone, may be protective against the development of dementia. Objective: To investigate the complex relationship between leptin levels and cognitive decline in elderly Italians. Methods: We studied circulating fasting leptin levels in 809 elderly adults free from dementia who participated in the prospective Italian population-based InCHIANTI study between 1998 and 2009 (mean follow-up of 8.0 years). Global cognitive decline was defined as a reduction of ≥5 points on the Mini-Mental State Examination (MMSE). Trail-Making Tests A and B were also incorporated, with cognitive decline defined as discontinued testing or the worst 10% of change from baseline. We also investigated whether any association could be explained by midlife weight and whether cognitive decline was associated with changing leptin levels. Results: The multivariate adjusted relative risk ([RR]; 95% confidence interval [CI]) of cognitive decline on the MMSE was 0.84 (95% CI 0.73–0.97) in relation to baseline sex-standardized log-leptin levels. High leptin levels showed a non-significant trend toward a reduced risk of decline on the Trail-Making Tests A (RR = 0.85, 95% CI 0.71–1.02) and B (RR = 0.90, 0.79–1.02). Adjusting for midlife weight or change in weight did not alter the pattern of results, and cognitive decline was not associated with changing leptin levels. Conclusions: High leptin levels were independently associated with a reduced risk of cognitive decline in elderly Italians. | en_GB |
dc.description.sponsorship | Italian Ministry of Health | en_GB |
dc.description.sponsorship | U.S. National Institute on Aging | en_GB |
dc.description.sponsorship | Alzheimer’s Association | en_GB |
dc.description.sponsorship | National Institute for Health Research (NIHR) | en_GB |
dc.description.sponsorship | National Institute of Health (Baltimore) | en_GB |
dc.description.sponsorship | National Institute of Health (Maryland) | en_GB |
dc.description.sponsorship | Mary Kinross Charitable Trust | en_GB |
dc.description.sponsorship | James Tudor Foundation | en_GB |
dc.description.sponsorship | Halpin Trust | en_GB |
dc.description.sponsorship | Sir Halley Stewart Trust | en_GB |
dc.description.sponsorship | Age Related Diseases and Health Trust | en_GB |
dc.description.sponsorship | Norman Family Charitable Trust | en_GB |
dc.identifier.citation | Vol. 44, Issue 4, pp. 1231 - 1239 | en_GB |
dc.identifier.doi | 10.3233/JAD-141836 | |
dc.identifier.grantnumber | ICS110.1/RF97.71 | en_GB |
dc.identifier.grantnumber | Contract: 263 | en_GB |
dc.identifier.grantnumber | Contract: 9164 | en_GB |
dc.identifier.grantnumber | Contract: 821336 | en_GB |
dc.identifier.grantnumber | N.1-AG-1-1 | en_GB |
dc.identifier.grantnumber | N.1-AG-1- 2111 | en_GB |
dc.identifier.grantnumber | N01-AG-5-0002 | en_GB |
dc.identifier.grantnumber | NIRG-11-200737 | en_GB |
dc.identifier.other | 06665306116808R6 | |
dc.identifier.uri | http://hdl.handle.net/10871/19978 | |
dc.language.iso | en | en_GB |
dc.publisher | IOS Press | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25502764 | en_GB |
dc.rights | © 2015 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License. | en_GB |
dc.subject | Adipokines | en_GB |
dc.subject | cognitive decline | en_GB |
dc.subject | cohort analysis | en_GB |
dc.subject | epidemiology | en_GB |
dc.subject | leptin | en_GB |
dc.title | Serum leptin and risk of cognitive decline in elderly italians. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-02-19T14:40:59Z | |
dc.identifier.issn | 1387-2877 | |
exeter.place-of-publication | Netherlands | |
dc.identifier.journal | Journal of Alzheimer's Disease | en_GB |