dc.contributor.author | Freathy, RM | |
dc.contributor.author | Mitchell, SM | |
dc.contributor.author | Knight, BA | |
dc.contributor.author | Shields, B | |
dc.contributor.author | Weedon, Michael N. | |
dc.contributor.author | Hattersley, Andrew T. | |
dc.contributor.author | Frayling, Timothy M. | |
dc.date.accessioned | 2016-02-23T14:54:44Z | |
dc.date.issued | 2006 | |
dc.description.abstract | BACKGROUND: Reduced growth during infancy is associated with adult insulin resistance. In a UK Caucasian cohort, the CSH1.01 microsatellite polymorphism in the growth hormone-chorionic somatomammotropin hormone gene cluster was recently associated with increases in adult fasting insulin of approximately 23 pmol/l for TT homozygote males compared to D1D1 or D2D2 homozygotes (P = 0.001 and 0.009; n = 206 and 92, respectively), but not for females. TT males additionally had a 547-g lower weight at 1 year (n = 270; P = 0.008) than D2D2 males. We sought to replicate these data in healthy UK Caucasian subjects. We genotyped 1396 subjects (fathers, mothers and children) from a consecutive birth study for the CSH1.01 marker and analysed genotypes for association with 1-year weight in boys and fasting insulin in fathers. RESULTS: We found no evidence for association of CSH1.01 genotype with adult male fasting insulin concentrations (TT/D1D1 P = 0.38; TT/D2D2 P = 0.18) or weight at 1 year in boys (TT/D1D1 P = 0.76; TT/D2D2 P = 0.85). For fasting insulin, our data can exclude the previously observed effect sizes as the 95 % confidence intervals for the differences observed in our study exclude increases in fasting insulin of 9.0 and 12.6 pmol/l for TT relative to D1D1 and D2D2 homozygotes, respectively. Whilst we have fewer data on boys' 1-year weight than the original study, our data can exclude a reduction in 1-year weight greater than 557 g for TT relative to D2D2 homozygotes. CONCLUSION: We have not found association of the CSH1.01 genotype with fasting insulin or weight at 1 year. We conclude that the original study is likely to have over-estimated the effect size for fasting insulin, or that the difference in results reflects the younger age of subjects in this study relative to those in the previous study. | en_GB |
dc.identifier.citation | Vol. 5, pp. 18 - ? | en_GB |
dc.identifier.doi | 10.1186/1477-5751-5-18 | |
dc.identifier.uri | http://hdl.handle.net/10871/20084 | |
dc.language.iso | en | en_GB |
dc.publisher | BioMed Central | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/17125497 | en_GB |
dc.rights | Copyright © 2006 Freathy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Body Weight | en_GB |
dc.subject | Cohort Studies | en_GB |
dc.subject | European Continental Ancestry Group | en_GB |
dc.subject | Fasting | en_GB |
dc.subject | Fathers | en_GB |
dc.subject | Female | en_GB |
dc.subject | Genetic Variation | en_GB |
dc.subject | Genotype | en_GB |
dc.subject | Great Britain | en_GB |
dc.subject | Growth Hormone | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Infant | en_GB |
dc.subject | Insulin | en_GB |
dc.subject | Male | en_GB |
dc.subject | Microsatellite Repeats | en_GB |
dc.subject | Multigene Family | en_GB |
dc.subject | Osmolar Concentration | en_GB |
dc.subject | Phenotype | en_GB |
dc.subject | Placental Lactogen | en_GB |
dc.subject | Polymorphism, Genetic | en_GB |
dc.title | A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-02-23T14:54:44Z | |
dc.identifier.issn | 1477-5751 | |
exeter.place-of-publication | England | |
dc.description | Published online | en_GB |
dc.description | Journal Article | en_GB |
dc.description | Research Support, Non-U.S. Gov't | en_GB |
dc.identifier.journal | Journal of Negative Results in BioMedicine | en_GB |
dc.identifier.pmcid | PMC1665461 | |