dc.contributor.author | Eigl, S | |
dc.contributor.author | Prattes, J | |
dc.contributor.author | Lackner, M | |
dc.contributor.author | Willinger, B | |
dc.contributor.author | Spiess, B | |
dc.contributor.author | Reinwald, M | |
dc.contributor.author | Selitsch, B | |
dc.contributor.author | Meilinger, M | |
dc.contributor.author | Neumeister, P | |
dc.contributor.author | Reischies, F | |
dc.contributor.author | Wölfler, A | |
dc.contributor.author | Raggam, RB | |
dc.contributor.author | Flick, H | |
dc.contributor.author | Eschertzhuber, S | |
dc.contributor.author | Krause, R | |
dc.contributor.author | Buchheidt, D | |
dc.contributor.author | Thornton, CR | |
dc.contributor.author | Lass-Flörl, C | |
dc.contributor.author | Hoenigl, M | |
dc.date.accessioned | 2016-02-26T09:46:03Z | |
dc.date.issued | 2015-04-17 | |
dc.description.abstract | INTRODUCTION: The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis of the disease and treatment with antifungal drugs is critical for patient survival. Serum biomarker tests for IPA typically give false-negative results in non-neutropenic patients, and galactomannan (GM) detection, the preferred diagnostic test for IPA using bronchoalveolar lavage (BAL), is often not readily available. Novel approaches to IPA detection in ICU patients are needed. In this multicenter study, we evaluated the performance of an Aspergillus lateral-flow device (LFD) test for BAL IPA detection in critically ill patients. METHODS: A total of 149 BAL samples from 133 ICU patients were included in this semiprospective study. Participating centers were the medical university hospitals of Graz, Vienna and Innsbruck in Austria and the University Hospital of Mannheim, Germany. Fungal infections were classified according to modified European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. RESULTS: Two patients (four BALs) had proven IPA, fourteen patients (sixteen BALs) had probable IPA, twenty patients (twenty-one BALs) had possible IPA and ninety-seven patients (one hundred eight BALs) did not fulfill IPA criteria. Sensitivity, specificity, negative predictive value, positive predictive value and diagnostic odds ratios for diagnosing proven and probable IPA using LFD tests of BAL were 80%, 81%, 96%, 44% and 17.6, respectively. Fungal BAL culture exhibited a sensitivity of 50% and a specificity of 85%. CONCLUSION: LFD tests of BAL showed promising results for IPA diagnosis in ICU patients. Furthermore, the LFD test can be performed easily and provides rapid results. Therefore, it may be a reliable alternative for IPA diagnosis in ICU patients if GM results are not rapidly available. TRIAL REGISTRATION: ClinicalTrials.gov NCT02058316. Registered 20 January 2014. | en_GB |
dc.description.sponsorship | Pfizer | en_GB |
dc.description.sponsorship | Oesterreichische Nationalbank (Anniversary Fund, project number 15346). | en_GB |
dc.identifier.citation | Vol. 19, pp. 178 - | en_GB |
dc.identifier.doi | 10.1186/s13054-015-0905-x | |
dc.identifier.grantnumber | WI174981 | en_GB |
dc.identifier.grantnumber | 15346 | en_GB |
dc.identifier.other | 10.1186/s13054-015-0905-x | |
dc.identifier.uri | http://hdl.handle.net/10871/20142 | |
dc.language.iso | en | en_GB |
dc.publisher | BioMed Central | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25927915 | en_GB |
dc.relation.url | http://ccforum.biomedcentral.com/articles/10.1186/s13054-015-0905-x | en_GB |
dc.rights | Copyright © Eigl et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Aged | en_GB |
dc.subject | Aged, 80 and over | en_GB |
dc.subject | Bronchoalveolar Lavage Fluid | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Intensive Care Units | en_GB |
dc.subject | Invasive Pulmonary Aspergillosis | en_GB |
dc.subject | Male | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | Prospective Studies | en_GB |
dc.subject | Young Adult | en_GB |
dc.title | Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-02-26T09:46:03Z | |
dc.identifier.issn | 1364-8535 | |
exeter.place-of-publication | England | |
dc.description | Published online | en_GB |
dc.description | Clinical Trial | en_GB |
dc.description | Journal Article | en_GB |
dc.description | Multicenter Study | en_GB |
dc.description | Research Support, Non-U.S. Gov't | en_GB |
dc.identifier.eissn | 1466-609X | |
dc.identifier.journal | Critical Care | en_GB |