Application of ex vivo cryo-imaging technique for three-dimensional finite element analysis of atherosclerotic plaque rupture
Abdul-Aziz, Ahmad A.; Cotton, Ross; Richards, Simon; et al.Faramarzalian, Ali; Young, Philippe G.; Chamie, Daniel; Wilson, David L.; Bezerra, Hiram G.; Costa, Marco A.
Date: 30 August 2015
Journal
Journal of Biomedical Engineering and Medical Imaging
Publisher
Society for Science and Education, United Kingdom
Publisher DOI
Abstract
Cryo-imaging is an ex vivo vascular imaging modality that acquires serial 2D fluorescence and bright-field images at 20μm increments without sacrifice to tissue morphology. These features make Cryo-imaging an attractive approach for rendering high-resolution 3D volumes that may serve as a basis for finite element analysis (FEA) studies ...
Cryo-imaging is an ex vivo vascular imaging modality that acquires serial 2D fluorescence and bright-field images at 20μm increments without sacrifice to tissue morphology. These features make Cryo-imaging an attractive approach for rendering high-resolution 3D volumes that may serve as a basis for finite element analysis (FEA) studies of plaque rupture. This work demonstrates the first use of Cryo-imaging for the imaging of a human coronary vessel and the subsequent rendering of a 3D FE model that clearly delineates critical anatomical features of atherosclerotic plaque. FEA is then performed to assess the plaque rupture conditions that result in a thrombotic episode.
Engineering
Faculty of Environment, Science and Economy
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