Application of ex vivo cryo-imaging technique for three-dimensional finite element analysis of atherosclerotic plaque rupture
Abdul-Aziz, Ahmad A.
Young, Philippe G.
Wilson, David L.
Bezerra, Hiram G.
Costa, Marco A.
Journal of Biomedical Engineering and Medical Imaging
Society for Science and Education, United Kingdom
Copyright © Society for Science and Education, United Kingdom. Open access journal
Cryo-imaging is an ex vivo vascular imaging modality that acquires serial 2D fluorescence and bright-field images at 20μm increments without sacrifice to tissue morphology. These features make Cryo-imaging an attractive approach for rendering high-resolution 3D volumes that may serve as a basis for finite element analysis (FEA) studies of plaque rupture. This work demonstrates the first use of Cryo-imaging for the imaging of a human coronary vessel and the subsequent rendering of a 3D FE model that clearly delineates critical anatomical features of atherosclerotic plaque. FEA is then performed to assess the plaque rupture conditions that result in a thrombotic episode.
Vol. 2, no.4