Show simple item record

TOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052].

dc.contributor.authorCross, PL
dc.contributor.authorAshby, D
dc.contributor.authorHarding, G
dc.contributor.authorHennessy, EM
dc.contributor.authorLetley, L
dc.contributor.authorParsons, S
dc.contributor.authorSpencer, AE
dc.contributor.authorUnderwood, M
dc.contributor.authorTOIB Study Team
dc.date.accessioned2016-03-24T13:36:10Z
dc.date.issued2005-11-07
dc.description.abstractMany older people have chronic knee pain. Both topical and oral non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this. Oral NSAIDS are effective, at least in the short term, but can have severe adverse effects. Topical NSAIDs also appear to be effective, at least in the short term. One might expect topical NSAIDs both to be less effective and to have fewer adverse effects than oral NSAIDs. If topical NSAIDs have fewer adverse effects this may outweigh both the reduction in effectiveness and the higher cost of topical compared to oral treatment. Patient preferences may influence the comparative effectiveness of drugs delivered via different routes.en_GB
dc.description.sponsorshipThe research costs for this study have been provided by the NHS Health Technology Assessment Programme. NHS R&D have provided NHS excess treatment and service support costs. We are grateful to Goldshield Pharmaceuticals for starter packs of topical ibuprofen. We are grateful to Helen Tate for statistical advice on study design and to Miranda Mugford for advice on health economic analysis. TOIB is a collaborative project between the Centre for Health Sciences at Barts and The London and the Medical Research Council General Practice Research Framework. We would like to acknowledge the contributions made by the funding applicants (Ashby D, Feder G, Harding G, Martin J, Parsons S, Spencer A, Underwood M (PI), Vickers M), the study team (Cross P, Hennessy E, Letley L, Shah H, Underwood M, Whyte K), the Trial Steering Committee (Ashby D, Buszewicz M, Carr A, Cross P, Grimley-Evans J, Hay E. Hennessey E, Lemon S, Letley L, Little P, Martin J, Shah H, Shine U, Underwood M, Vickers M, Whyte K), and the Data Monitoring and Ethics Committee (Adebajo A, Hennessey E, Morris R, Smeeth L). We would also like to thank the GPRF lead GPs, nurses and regional trainers involved in the TOIB study.en_GB
dc.identifier.citationVol. 6, pp. 55 -en_GB
dc.identifier.doi10.1186/1471-2474-6-55
dc.identifier.other1471-2474-6-55
dc.identifier.urihttp://hdl.handle.net/10871/20834
dc.language.isoenen_GB
dc.publisherBioMed Centralen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/16274477en_GB
dc.relation.urlhttp://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-6-55en_GB
dc.rightsThis is the final version of the article. Available from BioMed Central via the DOI in this record.en_GB
dc.subjectAdministration, Oralen_GB
dc.subjectAdministration, Topicalen_GB
dc.subjectAnalgesics, Non-Narcoticen_GB
dc.subjectChronic Diseaseen_GB
dc.subjectCost-Benefit Analysisen_GB
dc.subjectDrug Costsen_GB
dc.subjectHumansen_GB
dc.subjectIbuprofenen_GB
dc.subjectKneeen_GB
dc.subjectMiddle Ageden_GB
dc.subjectPainen_GB
dc.subjectPatient Satisfactionen_GB
dc.subjectPrimary Health Careen_GB
dc.titleTOIB Study. Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain presenting in primary care: a randomised controlled trial with patient preference study. [ISRCTN79353052].en_GB
dc.typeArticleen_GB
dc.date.available2016-03-24T13:36:10Z
dc.identifier.issn1471-2474
exeter.place-of-publicationEngland
dc.descriptionnotes: PMCID: PMC1314890en_GB
dc.descriptiontypes: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov'ten_GB
dc.identifier.journalBMC Musculoskeletal Disordersen_GB


Files in this item

Name:
BMC Musculoskeletal Disorders ...
Size:
481.2Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record