dc.contributor.author | Neal, RD | |
dc.contributor.author | Tharmanathan, P | |
dc.contributor.author | France, B | |
dc.contributor.author | Din, NU | |
dc.contributor.author | Cotton, S | |
dc.contributor.author | Fallon-Ferguson, J | |
dc.contributor.author | Hamilton, W | |
dc.contributor.author | Hendry, A | |
dc.contributor.author | Hendry, M | |
dc.contributor.author | Lewis, R | |
dc.contributor.author | Macleod, U | |
dc.contributor.author | Mitchell, ED | |
dc.contributor.author | Pickett, M | |
dc.contributor.author | Rai, T | |
dc.contributor.author | Shaw, K | |
dc.contributor.author | Stuart, N | |
dc.contributor.author | Tørring, ML | |
dc.contributor.author | Wilkinson, C | |
dc.contributor.author | Williams, B | |
dc.contributor.author | Williams, N | |
dc.contributor.author | Emery, J | |
dc.date.accessioned | 2016-05-27T07:22:00Z | |
dc.date.issued | 2015-03-31 | |
dc.description.abstract | BACKGROUND: It is unclear whether more timely cancer diagnosis brings favourable outcomes, with much of the previous evidence, in some cancers, being equivocal. We set out to determine whether there is an association between time to diagnosis, treatment and clinical outcomes, across all cancers for symptomatic presentations. METHODS: Systematic review of the literature and narrative synthesis. RESULTS: We included 177 articles reporting 209 studies. These studies varied in study design, the time intervals assessed and the outcomes reported. Study quality was variable, with a small number of higher-quality studies. Heterogeneity precluded definitive findings. The cancers with more reports of an association between shorter times to diagnosis and more favourable outcomes were breast, colorectal, head and neck, testicular and melanoma. CONCLUSIONS: This is the first review encompassing many cancer types, and we have demonstrated those cancers in which more evidence of an association between shorter times to diagnosis and more favourable outcomes exists, and where it is lacking. We believe that it is reasonable to assume that efforts to expedite the diagnosis of symptomatic cancer are likely to have benefits for patients in terms of improved survival, earlier-stage diagnosis and improved quality of life, although these benefits vary between cancers. | en_GB |
dc.description.sponsorship | The original study and the update were funded by Cancer Research
UK (grants C8350/A8870 and C8350/A17915, through EDAG–
Early Diagnosis Advisory Group). RDN also receives funding from
Public Health Wales and Betsi Cadwaladr University Health Board.
We thank other members of the ABC-DEEP consortium who did
not contribute directly to this review but gave valuable advice
throughout the study. We also thank others who contributed to the
original review. We also thank staff at Cancer Research UK for
their support and feedback throughout the review. Last, we thank
Emma Kennerley for administrative support. We acknowledge that
two of the co-authors (RDN and MLT) were also authors of papers
included in the review. These papers were independently assessed
by other members of the research team. The updated review is
registered with PROSPERO (http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014006301). | en_GB |
dc.identifier.citation | Vol. 112 Suppl 1, pp. S92 - 107 | en_GB |
dc.identifier.doi | 10.1038/bjc.2015.48 | |
dc.identifier.other | bjc201548 | |
dc.identifier.uri | http://hdl.handle.net/10871/21706 | |
dc.language.iso | en | en_GB |
dc.publisher | Cancer Research UK and Nature Publishing Group | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25734382 | en_GB |
dc.rights | Thisworkislicensed under theCreativeCommons
Attribution 4.0 International License. To view a
copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_GB |
dc.subject | Delayed Diagnosis | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Neoplasms | en_GB |
dc.subject | Prognosis | en_GB |
dc.subject | Time-to-Treatment | en_GB |
dc.title | Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-05-27T07:22:00Z | |
exeter.place-of-publication | England | |
dc.description | This is the final version of the article. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | British Journal of Cancer | en_GB |
dc.identifier.pmcid | PMC4385982 | |
dc.identifier.pmid | 25734382 | |