dc.contributor.author | Da Boit, Mariasole | |
dc.contributor.author | Sibson, Rachael | |
dc.contributor.author | Meakin, JR | |
dc.contributor.author | Aspden, Richard M. | |
dc.contributor.author | Thies, Frank | |
dc.contributor.author | Mangoni, Arduino A. | |
dc.contributor.author | Gray, Stuart Robert | |
dc.date.accessioned | 2016-05-27T11:53:51Z | |
dc.date.issued | 2016-06-28 | |
dc.description.abstract | Resistance exercise training is known to be effective in increasing muscle mass in older people. Acute measurement of protein metabolism data has indicated that the magnitude of response may differ between sexes. We compared adaptive responses in muscle mass and function to 18 weeks resistance exercise training in a cohort of older (>65years) males and females. Resistance exercise training improved knee extensor maximal torque, 4 m walk time, time to complete 5 chair rises, muscle anatomical cross sectional area (ACSA) and muscle quality with no effect on muscle fat/water ratio or plasma glucose, insulin, triacylglycerol, IL-6 and TNF-α. Differences between sexes were observed for knee extensor maximal torque and muscle quality with greater increases observed in males vs females (P<0.05). Maximal torque increased by 15.8 ± 10.6 % in females and 41.7 ± 25.5 % in males whilst muscle quality increased by 8.8 ± 17.5 % in women and by 33.7 ± 25.6 % in men. In conclusion the current study has demonstrated a difference in the magnitude of adaptation, of some of the outcome measures employed, in response to 18 weeks of resistance exercise training between males and females. The mechanisms underlying this observation remains to be established | en_GB |
dc.description.sponsorship | This work was supported by the Biotechnology and Biological Sciences Research Council (BB/J015911/1) | en_GB |
dc.identifier.citation | Vol. 4, Iss. 12, June 2016 | |
dc.identifier.uri | http://hdl.handle.net/10871/21727 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.rights | This is the author accepted manuscript. The final version is available from Wiley Open Access via the DOI in this record. | |
dc.subject | Muscle adaptation | en_GB |
dc.subject | exercise | en_GB |
dc.subject | ageing | en_GB |
dc.subject | sexual dimorphism | en_GB |
dc.title | Sex differences in the response to resistance exercise training in older people | en_GB |
dc.type | Article | en_GB |
dc.identifier.issn | 2051-817X | |
dc.identifier.journal | Physiological Reports | en_GB |