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dc.contributor.authorWood, AR
dc.contributor.authorEsko, T
dc.contributor.authorYang, J
dc.contributor.authorVedantam, S
dc.contributor.authorPers, TH
dc.contributor.authorGustafsson, S
dc.contributor.authorChu, AY
dc.contributor.authorEstrada, K
dc.contributor.authorLuan, J
dc.contributor.authorKutalik, Z
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dc.contributor.authorBuchkovich, ML
dc.contributor.authorCroteau-Chonka, DC
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dc.contributor.authorFall, T
dc.contributor.authorFehrmann, R
dc.contributor.authorFerreira, T
dc.contributor.authorJackson, AU
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dc.contributor.authorLo, KS
dc.contributor.authorLocke, AE
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dc.contributor.authorMihailov, E
dc.contributor.authorPorcu, E
dc.contributor.authorRandall, JC
dc.contributor.authorScherag, A
dc.contributor.authorVinkhuyzen, AA
dc.contributor.authorWestra, HJ
dc.contributor.authorWinkler, TW
dc.contributor.authorWorkalemahu, T
dc.contributor.authorZhao, JH
dc.contributor.authorAbsher, D
dc.contributor.authorAlbrecht, E
dc.contributor.authorAnderson, D
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dc.contributor.authorBeekman, M
dc.contributor.authorDemirkan, A
dc.contributor.authorEhret, GB
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dc.contributor.authorFeitosa, MF
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dc.contributor.authorJustice, AE
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dc.contributor.authorElectronic Medical Records and Genomics (eMEMERGEGE) Consortium
dc.contributor.authorMIGen Consortium
dc.contributor.authorPAGEGE Consortium
dc.contributor.authorLifeLines Cohort Study
dc.contributor.authorAmouyel, P
dc.contributor.authorAsselbergs, FW
dc.contributor.authorAssimes, TL
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dc.contributor.authorvan der Harst, P
dc.contributor.authorVölzke, H
dc.contributor.authorWalker, M
dc.contributor.authorWareham, NJ
dc.contributor.authorWatkins, H
dc.contributor.authorWichmann, HE
dc.contributor.authorWilson, JF
dc.contributor.authorZanen, P
dc.contributor.authorDeloukas, P
dc.contributor.authorHeid, IM
dc.contributor.authorLindgren, CM
dc.contributor.authorMohlke, KL
dc.contributor.authorSpeliotes, EK
dc.contributor.authorThorsteinsdottir, U
dc.contributor.authorBarroso, I
dc.contributor.authorFox, CS
dc.contributor.authorNorth, KE
dc.contributor.authorStrachan, DP
dc.contributor.authorBeckmann, JS
dc.contributor.authorBerndt, SI
dc.contributor.authorBoehnke, M
dc.contributor.authorBorecki, IB
dc.contributor.authorMcCarthy, MI
dc.contributor.authorMetspalu, A
dc.contributor.authorStefansson, K
dc.contributor.authorUitterlinden, AG
dc.contributor.authorvan Duijn, CM
dc.contributor.authorFranke, L
dc.contributor.authorWiller, CJ
dc.contributor.authorPrice, AL
dc.contributor.authorLettre, G
dc.contributor.authorLoos, RJ
dc.contributor.authorWeedon, MN
dc.contributor.authorIngelsson, E
dc.contributor.authorO'Connell, JR
dc.contributor.authorAbecasis, GR
dc.contributor.authorChasman, DI
dc.contributor.authorGoddard, ME
dc.contributor.authorVisscher, PM
dc.contributor.authorHirschhorn, JN
dc.contributor.authorFrayling, TM
dc.date.accessioned2016-07-12T10:57:32Z
dc.date.issued2014-10-05
dc.description.abstractUsing genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.en_GB
dc.identifier.citationNature Genetics, 2014, Vol. 46, pp. 1173 - 1186en_GB
dc.identifier.doi10.1038/ng.3097
dc.identifier.urihttp://hdl.handle.net/10871/22509
dc.language.isoenen_GB
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25282103en_GB
dc.rightsThis is the author accepted manuscript. The final version is available from Nature via the DOI in this record.en_GB
dc.subjectAdulten_GB
dc.subjectAnalysis of Varianceen_GB
dc.subjectBody Heighten_GB
dc.subjectEuropean Continental Ancestry Groupen_GB
dc.subjectGenetic Variationen_GB
dc.subjectGenetics, Populationen_GB
dc.subjectGenome-Wide Association Studyen_GB
dc.subjectHumansen_GB
dc.subjectOligonucleotide Array Sequence Analysisen_GB
dc.subjectPolymorphism, Single Nucleotideen_GB
dc.titleDefining the role of common variation in the genomic and biological architecture of adult human height.en_GB
dc.typeArticleen_GB
dc.date.available2016-07-12T10:57:32Z
dc.identifier.issn1061-4036
exeter.place-of-publicationUnited States
dc.descriptionMeta-Analysisen_GB
dc.identifier.journalNature Geneticsen_GB


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