dc.contributor.author | Kuijper, B | |
dc.contributor.author | Lane, N | |
dc.contributor.author | Pomiankowski, A | |
dc.date.accessioned | 2016-07-21T09:12:37Z | |
dc.date.issued | 2015-02 | |
dc.description.abstract | A growing number of studies in multicellular organisms highlight low or
moderate frequencies of paternal transmission of cytoplasmic organelles,
including both mitochondria and chloroplasts. It is well established that
strict maternal inheritance is selectively blind to cytoplasmic elements that
are deleterious to males – ’mother’s curse’. But it is not known how sensitive
this conclusion is to slight levels of paternal cytoplasmic leakage. We
assess the scope for polymorphism when individuals bear multiple cytoplasmic
alleles in the presence of paternal leakage, bottlenecks and recurrent
mutation. When fitness interactions among cytoplasmic elements within an
individual are additive, we find that sexually antagonistic polymorphism is
restricted to cases of strong selection on males. However, when fitness interactions
among cytoplasmic elements are nonlinear, much more extensive
polymorphism can be supported in the cytoplasm. In particular, mitochondrial
mutants that have strong beneficial fitness effects in males and weak
deleterious fitness effects in females when rare (i.e. ’reverse dominance’)
are strongly favoured under paternal leakage. We discuss how such epistasis
could arise through preferential segregation of mitochondria in sex-specific
somatic tissues. Our analysis shows how paternal leakage can dampen the
evolution of deleterious male effects associated with predominant maternal
inheritance of cytoplasm, potentially explaining why ’mother’s curse’ is less
pervasive than predicted by earlier work. | en_GB |
dc.description.sponsorship | This study was funded by an EPSRC-funded 2020 Science
fellowship (EP/I017909/1). We thank Andy Gardner
and two anonymous reviewers for comments on
the manuscript. The authors acknowledge the use of
the UCL Legion High Performance Computing Facility
(Legion@UCL), and associated support services, in the
completion of this work. NL acknowledges support
from the Provost’s Venture Research Fellowship and
the Leverhulme Trust, and AP from the EPSRC (EP/
F500351/1, EP/I017909/1, EP/K038656/1) and NERC
(NE/G00563X/1). | en_GB |
dc.identifier.citation | Vol. 28, pp. 468 - 480 | en_GB |
dc.identifier.doi | 10.1111/jeb.12582 | |
dc.identifier.uri | http://hdl.handle.net/10871/22666 | |
dc.language.iso | en | en_GB |
dc.publisher | Wiley | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/25653025 | en_GB |
dc.rights | © 2015 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited | en_GB |
dc.subject | chloroplast | en_GB |
dc.subject | heteroplasmy | en_GB |
dc.subject | intralocus sexual conflict | en_GB |
dc.subject | maternal inheritance | en_GB |
dc.subject | mitochondria | en_GB |
dc.subject | mtDNA | en_GB |
dc.subject | organelle | en_GB |
dc.subject | sexual dimorphism | en_GB |
dc.title | Can paternal leakage maintain sexually antagonistic polymorphism in the cytoplasm? | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-07-21T09:12:37Z | |
dc.identifier.issn | 1010-061X | |
dc.description | This is the final version of the article. Available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Journal of Evolutionary Biology | en_GB |
dc.identifier.pmid | 25653025 | |
dc.identifier.pmid | PMC4413368 | |