dc.contributor.author | McCarthy, S | |
dc.contributor.author | Das, S | |
dc.contributor.author | Kretzschmar, W | |
dc.contributor.author | Delaneau, O | |
dc.contributor.author | Wood, AR | |
dc.contributor.author | Teumer, A | |
dc.contributor.author | Kang, HM | |
dc.contributor.author | Fuchsberger, C | |
dc.contributor.author | Danecek, P | |
dc.contributor.author | Sharp, K | |
dc.contributor.author | Luo, Y | |
dc.contributor.author | Sidore, C | |
dc.contributor.author | Kwong, A | |
dc.contributor.author | Timpson, N | |
dc.contributor.author | Koskinen, S | |
dc.contributor.author | Vrieze, S | |
dc.contributor.author | Scott, LJ | |
dc.contributor.author | Zhang, H | |
dc.contributor.author | Mahajan, A | |
dc.contributor.author | Veldink, J | |
dc.contributor.author | Peters, U | |
dc.contributor.author | Pato, C | |
dc.contributor.author | van Duijn, CM | |
dc.contributor.author | Gillies, CE | |
dc.contributor.author | Gandin, I | |
dc.contributor.author | Mezzavilla, M | |
dc.contributor.author | Gilly, A | |
dc.contributor.author | Cocca, M | |
dc.contributor.author | Traglia, M | |
dc.contributor.author | Angius, A | |
dc.contributor.author | Barrett, JC | |
dc.contributor.author | Boomsma, D | |
dc.contributor.author | Branham, K | |
dc.contributor.author | Breen, G | |
dc.contributor.author | Brummett, CM | |
dc.contributor.author | Busonero, F | |
dc.contributor.author | Campbell, H | |
dc.contributor.author | Chan, A | |
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dc.contributor.author | Chew, E | |
dc.contributor.author | Collins, FS | |
dc.contributor.author | Corbin, LJ | |
dc.contributor.author | Smith, GD | |
dc.contributor.author | Dedoussis, G | |
dc.contributor.author | Dorr, M | |
dc.contributor.author | Farmaki, AE | |
dc.contributor.author | Ferrucci, L | |
dc.contributor.author | Forer, L | |
dc.contributor.author | Fraser, RM | |
dc.contributor.author | Gabriel, S | |
dc.contributor.author | Levy, S | |
dc.contributor.author | Groop, L | |
dc.contributor.author | Harrison, T | |
dc.contributor.author | Hattersley, A | |
dc.contributor.author | Holmen, OL | |
dc.contributor.author | Hveem, K | |
dc.contributor.author | Kretzler, M | |
dc.contributor.author | Lee, JC | |
dc.contributor.author | McGue, M | |
dc.contributor.author | Meitinger, T | |
dc.contributor.author | Melzer, D | |
dc.contributor.author | Min, JL | |
dc.contributor.author | Mohlke, KL | |
dc.contributor.author | Vincent, JB | |
dc.contributor.author | Nauck, M | |
dc.contributor.author | Nickerson, D | |
dc.contributor.author | Palotie, A | |
dc.contributor.author | Pato, M | |
dc.contributor.author | Pirastu, N | |
dc.contributor.author | McInnis, M | |
dc.contributor.author | Richards, JB | |
dc.contributor.author | Sala, C | |
dc.contributor.author | Salomaa, V | |
dc.contributor.author | Schlessinger, D | |
dc.contributor.author | Schoenherr, S | |
dc.contributor.author | Slagboom, PE | |
dc.contributor.author | Small, K | |
dc.contributor.author | Spector, T | |
dc.contributor.author | Stambolian, D | |
dc.contributor.author | Tuke, M | |
dc.contributor.author | Tuomilehto, J | |
dc.contributor.author | Van den Berg, LH | |
dc.contributor.author | Van Rheenen, W | |
dc.contributor.author | Volker, U | |
dc.contributor.author | Wijmenga, C | |
dc.contributor.author | Toniolo, D | |
dc.contributor.author | Zeggini, E | |
dc.contributor.author | Gasparini, P | |
dc.contributor.author | Sampson, MG | |
dc.contributor.author | Wilson, JF | |
dc.contributor.author | Frayling, T | |
dc.contributor.author | de Bakker, PI | |
dc.contributor.author | Swertz, MA | |
dc.contributor.author | McCarroll, S | |
dc.contributor.author | Kooperberg, C | |
dc.contributor.author | Dekker, A | |
dc.contributor.author | Altshuler, D | |
dc.contributor.author | Willer, C | |
dc.contributor.author | Iacono, W | |
dc.contributor.author | Ripatti, S | |
dc.contributor.author | Soranzo, N | |
dc.contributor.author | Walter, K | |
dc.contributor.author | Swaroop, A | |
dc.contributor.author | Cucca, F | |
dc.contributor.author | Anderson, CA | |
dc.contributor.author | Myers, RM | |
dc.contributor.author | Boehnke, M | |
dc.contributor.author | McCarthy, MI | |
dc.contributor.author | Durbin, R | |
dc.contributor.author | Abecasis, G | |
dc.contributor.author | Marchini, J | |
dc.contributor.author | Haplotype Reference Consortium | |
dc.date.accessioned | 2016-09-19T09:34:38Z | |
dc.date.issued | 2016-08-22 | |
dc.description.abstract | We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently. | en_GB |
dc.description.sponsorship | J.M acknowledges support from the ERC (Grant no. 617306). W.K acknowledges
support from the Wellcome Trust (Grant no. WT097307). S.M and R.D
acknowledge support from Wellcome Trust grant WT090851. We are grateful to
all participants of all the studies that have contributed data to the HRC. | en_GB |
dc.identifier.citation | doi:10.1038/ng.3643 | en_GB |
dc.identifier.doi | 10.1038/ng.3643 | |
dc.identifier.other | ng.3643 | |
dc.identifier.uri | http://hdl.handle.net/10871/23512 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Publishing Group | en_GB |
dc.relation.url | http://www.ncbi.nlm.nih.gov/pubmed/27548312 | en_GB |
dc.rights | Pre print made available under a CC-BY-NC-ND 4.0 International license. | en_GB |
dc.subject | Genome-wide association studies | en_GB |
dc.subject | Population genetics | en_GB |
dc.title | A reference panel of 64,976 haplotypes for genotype imputation. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-09-19T09:34:38Z | |
dc.description | This is the author pre print version. The final version is available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Nature Genetics | en_GB |
dc.identifier.pmid | 27548312 | |