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A reference panel of 64,976 haplotypes for genotype imputation.

dc.contributor.authorMcCarthy, S
dc.contributor.authorDas, S
dc.contributor.authorKretzschmar, W
dc.contributor.authorDelaneau, O
dc.contributor.authorWood, AR
dc.contributor.authorTeumer, A
dc.contributor.authorKang, HM
dc.contributor.authorFuchsberger, C
dc.contributor.authorDanecek, P
dc.contributor.authorSharp, K
dc.contributor.authorLuo, Y
dc.contributor.authorSidore, C
dc.contributor.authorKwong, A
dc.contributor.authorTimpson, N
dc.contributor.authorKoskinen, S
dc.contributor.authorVrieze, S
dc.contributor.authorScott, LJ
dc.contributor.authorZhang, H
dc.contributor.authorMahajan, A
dc.contributor.authorVeldink, J
dc.contributor.authorPeters, U
dc.contributor.authorPato, C
dc.contributor.authorvan Duijn, CM
dc.contributor.authorGillies, CE
dc.contributor.authorGandin, I
dc.contributor.authorMezzavilla, M
dc.contributor.authorGilly, A
dc.contributor.authorCocca, M
dc.contributor.authorTraglia, M
dc.contributor.authorAngius, A
dc.contributor.authorBarrett, JC
dc.contributor.authorBoomsma, D
dc.contributor.authorBranham, K
dc.contributor.authorBreen, G
dc.contributor.authorBrummett, CM
dc.contributor.authorBusonero, F
dc.contributor.authorCampbell, H
dc.contributor.authorChan, A
dc.contributor.authorChen, S
dc.contributor.authorChew, E
dc.contributor.authorCollins, FS
dc.contributor.authorCorbin, LJ
dc.contributor.authorSmith, GD
dc.contributor.authorDedoussis, G
dc.contributor.authorDorr, M
dc.contributor.authorFarmaki, AE
dc.contributor.authorFerrucci, L
dc.contributor.authorForer, L
dc.contributor.authorFraser, RM
dc.contributor.authorGabriel, S
dc.contributor.authorLevy, S
dc.contributor.authorGroop, L
dc.contributor.authorHarrison, T
dc.contributor.authorHattersley, A
dc.contributor.authorHolmen, OL
dc.contributor.authorHveem, K
dc.contributor.authorKretzler, M
dc.contributor.authorLee, JC
dc.contributor.authorMcGue, M
dc.contributor.authorMeitinger, T
dc.contributor.authorMelzer, D
dc.contributor.authorMin, JL
dc.contributor.authorMohlke, KL
dc.contributor.authorVincent, JB
dc.contributor.authorNauck, M
dc.contributor.authorNickerson, D
dc.contributor.authorPalotie, A
dc.contributor.authorPato, M
dc.contributor.authorPirastu, N
dc.contributor.authorMcInnis, M
dc.contributor.authorRichards, JB
dc.contributor.authorSala, C
dc.contributor.authorSalomaa, V
dc.contributor.authorSchlessinger, D
dc.contributor.authorSchoenherr, S
dc.contributor.authorSlagboom, PE
dc.contributor.authorSmall, K
dc.contributor.authorSpector, T
dc.contributor.authorStambolian, D
dc.contributor.authorTuke, M
dc.contributor.authorTuomilehto, J
dc.contributor.authorVan den Berg, LH
dc.contributor.authorVan Rheenen, W
dc.contributor.authorVolker, U
dc.contributor.authorWijmenga, C
dc.contributor.authorToniolo, D
dc.contributor.authorZeggini, E
dc.contributor.authorGasparini, P
dc.contributor.authorSampson, MG
dc.contributor.authorWilson, JF
dc.contributor.authorFrayling, T
dc.contributor.authorde Bakker, PI
dc.contributor.authorSwertz, MA
dc.contributor.authorMcCarroll, S
dc.contributor.authorKooperberg, C
dc.contributor.authorDekker, A
dc.contributor.authorAltshuler, D
dc.contributor.authorWiller, C
dc.contributor.authorIacono, W
dc.contributor.authorRipatti, S
dc.contributor.authorSoranzo, N
dc.contributor.authorWalter, K
dc.contributor.authorSwaroop, A
dc.contributor.authorCucca, F
dc.contributor.authorAnderson, CA
dc.contributor.authorMyers, RM
dc.contributor.authorBoehnke, M
dc.contributor.authorMcCarthy, MI
dc.contributor.authorDurbin, R
dc.contributor.authorAbecasis, G
dc.contributor.authorMarchini, J
dc.contributor.authorHaplotype Reference Consortium
dc.date.accessioned2016-09-19T09:34:38Z
dc.date.issued2016-08-22
dc.description.abstractWe describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies, and it can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.en_GB
dc.description.sponsorshipJ.M acknowledges support from the ERC (Grant no. 617306). W.K acknowledges support from the Wellcome Trust (Grant no. WT097307). S.M and R.D acknowledge support from Wellcome Trust grant WT090851. We are grateful to all participants of all the studies that have contributed data to the HRC.en_GB
dc.identifier.citationdoi:10.1038/ng.3643en_GB
dc.identifier.doi10.1038/ng.3643
dc.identifier.otherng.3643
dc.identifier.urihttp://hdl.handle.net/10871/23512
dc.language.isoenen_GB
dc.publisherNature Publishing Groupen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/27548312en_GB
dc.rightsPre print made available under a CC-BY-NC-ND 4.0 International license.en_GB
dc.subjectGenome-wide association studiesen_GB
dc.subjectPopulation geneticsen_GB
dc.titleA reference panel of 64,976 haplotypes for genotype imputation.en_GB
dc.typeArticleen_GB
dc.date.available2016-09-19T09:34:38Z
dc.descriptionThis is the author pre print version. The final version is available from the publisher via the DOI in this record.en_GB
dc.identifier.journalNature Geneticsen_GB
dc.identifier.pmid27548312


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