dc.contributor.author | Bowen, A | |
dc.contributor.author | Kos, K | |
dc.contributor.author | Whatmore, J | |
dc.contributor.author | Richardson, S | |
dc.contributor.author | Welters, HJ | |
dc.date.accessioned | 2016-09-30T09:59:45Z | |
dc.date.issued | 2016-09-28 | |
dc.description.abstract | The Wnt signalling pathway in beta-cells has been linked to the development of type 2 diabetes. Investigating the impact of a non-canonical Wnt ligand, Wnt4, on beta-cell function we found that in INS-1 cells, Wnt4 was able to completely block Wnt3a stimulated cell growth and insulin secretion. However, despite high levels of Wnt4 protein being detected in INS-1 cells, reducing the expression of Wnt4 had no impact on cell growth or Wnt3a signalling. As such, the role of the endogenously expressed Wnt4 in beta-cells is unclear, but the data showing that Wnt4 can act as a negative regulator of canonical Wnt signalling in beta-cells suggests that this pathway could be a potential target for modulating beta-cell function. | en_GB |
dc.description.sponsorship | This work was supported by the Northcott Devon Medical Foundation (grant TB/MG/NO5002/141109 to HJW). | en_GB |
dc.identifier.citation | Available online 28 September 2016 | en_GB |
dc.identifier.doi | 10.1016/j.bbrc.2016.09.130 | |
dc.identifier.uri | http://hdl.handle.net/10871/23706 | |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights.embargoreason | Publisher policy | en_GB |
dc.subject | Wnt signalling | en_GB |
dc.subject | Wnt4 | en_GB |
dc.subject | Islet cells | en_GB |
dc.subject | Insulin secretion | en_GB |
dc.subject | Cell growth control | en_GB |
dc.title | Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1 | en_GB |
dc.type | Article | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record. | en_GB |
dc.identifier.journal | Biochemical and Biophysical Research Communications | en_GB |