dc.contributor.author | Kimura, M | |
dc.contributor.author | Cherkas, LF | |
dc.contributor.author | Kato, BS | |
dc.contributor.author | Demissie, S | |
dc.contributor.author | Hjelmborg, JB | |
dc.contributor.author | Brimacombe, M | |
dc.contributor.author | Cupples, A | |
dc.contributor.author | Hunkin, JL | |
dc.contributor.author | Gardner, JP | |
dc.contributor.author | Lu, X | |
dc.contributor.author | Cao, X | |
dc.contributor.author | Sastrasinh, M | |
dc.contributor.author | Province, MA | |
dc.contributor.author | Hunt, SC | |
dc.contributor.author | Christensen, K | |
dc.contributor.author | Levy, D | |
dc.contributor.author | Spector, TD | |
dc.contributor.author | Aviv, A | |
dc.date.accessioned | 2016-12-08T10:03:07Z | |
dc.date.issued | 2008-02-15 | |
dc.description.abstract | Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by delineating telomere parameters in sperm donors. We measured LTL by Southern blots in Caucasian men and women (n=3365), aged 18-94 years, from the Offspring of the Framingham Heart Study (Framingham Offspring), the NHLBI Family Heart Study (NHLBI-Heart), the Longitudinal Study of Aging Danish Twins (Danish Twins), and the UK Adult Twin Registry (UK Twins). Using Southern blots, Q-FISH, and flow-FISH, we also measured telomere parameters in sperm from 46 young (<30 years) and older (>50 years) donors. Paternal age had an independent effect, expressed by a longer LTL in males of the Framingham Offspring and Danish Twins, males and females of the NHLBI-Heart, and females of UK Twins. For every additional year of paternal age, LTL in offspring increased at a magnitude ranging from half to more than twice of the annual attrition in LTL with age. Moreover, sperm telomere length analyses were compatible with the emergence in older men of a subset of sperm with elongated telomeres. Paternal age exerts a considerable effect on the offspring's LTL, a phenomenon which might relate to telomere elongation in sperm from older men. The implications of this effect deserve detailed study. | en_GB |
dc.description.sponsorship | Supported by NIH grants R01-AG021593, R01-AG020132, and P01-AG0876. Support was also provided by NIH contract NOHC25195, the NHLBI cooperative agreement grants U01 HL 67893, U01 HL67894, U01 HL67895, U01 HL67896, U01 HL67897, U01 HL67898, U01 HL67899, U01 HL67900, U01 HL67901, U01 HL67902, U01 HL56563, U01 HL56564, U01 HL56565, U01 HL56566, U01 HL56567, U01 HL56568, and U01 HL56569. Also funded in part by the Wellcome Trust grant (ref 074951). | en_GB |
dc.identifier.citation | Vol. 4, Iss. 2, pp. e37 - | en_GB |
dc.identifier.doi | 10.1371/journal.pgen.0040037 | |
dc.identifier.other | 07-PLGE-RA-0631 | |
dc.identifier.uri | http://hdl.handle.net/10871/24776 | |
dc.language.iso | en | en_GB |
dc.publisher | Public Library of Science | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/18282113 | en_GB |
dc.rights | Copyright: © 2008 Kimura et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_GB |
dc.subject | Adolescent | en_GB |
dc.subject | Adult | en_GB |
dc.subject | Aged | en_GB |
dc.subject | Aged, 80 and over | en_GB |
dc.subject | Aging | en_GB |
dc.subject | Female | en_GB |
dc.subject | Humans | en_GB |
dc.subject | In Situ Hybridization, Fluorescence | en_GB |
dc.subject | Infant, Newborn | en_GB |
dc.subject | Leukocytes | en_GB |
dc.subject | Male | en_GB |
dc.subject | Maternal Age | en_GB |
dc.subject | Middle Aged | en_GB |
dc.subject | Paternal Age | en_GB |
dc.subject | Pregnancy | en_GB |
dc.subject | Regression Analysis | en_GB |
dc.subject | Spermatozoa | en_GB |
dc.subject | Telomere | en_GB |
dc.title | Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2016-12-08T10:03:07Z | |
dc.identifier.issn | 1553-7390 | |
exeter.place-of-publication | United States | en_GB |
dc.description | Published | en_GB |
dc.description | Journal Article | en_GB |
dc.description | Research Support, N.I.H., Extramural | en_GB |
dc.description | Research Support, Non-U.S. Gov't | en_GB |
dc.description | This is the final version of the article. Available from Public Library of Science via the DOI in this record. | en_GB |
dc.identifier.eissn | 1553-7404 | |
dc.identifier.journal | PLoS Genetics | en_GB |