dc.contributor.author | Wotton, KR | |
dc.contributor.author | Shimeld, SM | |
dc.date.accessioned | 2017-02-15T10:19:09Z | |
dc.date.issued | 2006-10-24 | |
dc.description.abstract | BACKGROUND: Vertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineages can often allow the evolutionary history of such regions to be traced. A classic example of this is the Hox genes, where the presence of a single continuous Hox cluster in amphioxus and four vertebrate clusters has allowed the genomic evolution of this region to be established. Fox transcription factors of the C, F, L1 and Q1 classes are also organised in clusters in both amphioxus and humans. However in contrast to the Hox genes, only two clusters of paralogous Fox genes have so far been identified in the Human genome and the organisation in other vertebrates is unknown. RESULTS: To uncover the evolutionary history of the Fox clusters, we report on the comparative genomics of these loci. We demonstrate two further paralogous regions in the Human genome, and identify orthologous regions in mammalian, chicken, frog and teleost genomes, timing the duplications to before the separation of the actinopterygian and sarcopterygian lineages. An additional Fox class, FoxS, was also found to reside in this duplicated genomic region. CONCLUSION: Comparison of loci identifies the pattern of gene duplication, loss and cluster break up through multiple lineages, and suggests FoxS1 is a likely remnant of Fox cluster duplication. | en_GB |
dc.description.sponsorship | We thank Peter Holland and Dave Ferrier for their discussions on this project and John Mulley for supplying the Amia calva genomic DNA, and for comments on the manuscript. This work was supported by the BBSRC. | en_GB |
dc.identifier.citation | Vol. 7, pp. 271 - | en_GB |
dc.identifier.doi | 10.1186/1471-2164-7-271 | |
dc.identifier.other | 1471-2164-7-271 | |
dc.identifier.uri | http://hdl.handle.net/10871/25870 | |
dc.language.iso | en | en_GB |
dc.publisher | BioMed Central | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/17062144 | en_GB |
dc.rights | © Wotton and Shimeld; licensee BioMed Central Ltd. 2006 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_GB |
dc.subject | Animals | en_GB |
dc.subject | Chickens | en_GB |
dc.subject | Chromosome Mapping | en_GB |
dc.subject | Chromosomes, Human, Pair 14 | en_GB |
dc.subject | Chromosomes, Human, Pair 16 | en_GB |
dc.subject | Chromosomes, Human, Pair 20 | en_GB |
dc.subject | Chromosomes, Human, Pair 6 | en_GB |
dc.subject | Evolution, Molecular | en_GB |
dc.subject | Fishes | en_GB |
dc.subject | Forkhead Transcription Factors | en_GB |
dc.subject | Gene Duplication | en_GB |
dc.subject | Genome, Human | en_GB |
dc.subject | Genomics | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Mammals | en_GB |
dc.subject | Mice | en_GB |
dc.subject | Models, Genetic | en_GB |
dc.subject | Multigene Family | en_GB |
dc.subject | Phylogeny | en_GB |
dc.subject | Synteny | en_GB |
dc.subject | Xenopus | en_GB |
dc.title | Comparative genomics of vertebrate Fox cluster loci. | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-02-15T10:19:09Z | |
exeter.place-of-publication | England | en_GB |
dc.description | Published online | en_GB |
dc.description | Comparative Study | en_GB |
dc.description | Journal Article | en_GB |
dc.description | Research Support, Non-U.S. Gov't | en_GB |
dc.description | This is the final version of the article. Available from BioMed Central via the DOI in this record. | en_GB |
dc.identifier.eissn | 1471-2164 | |
dc.identifier.journal | BMC Genomics | en_GB |