dc.contributor.author | Freathy, RM | |
dc.contributor.author | Mook-Kanamori, DO | |
dc.contributor.author | Sovio, U | |
dc.contributor.author | Prokopenko, I | |
dc.contributor.author | Timpson, NJ | |
dc.contributor.author | Berry, DJ | |
dc.contributor.author | Warrington, NM | |
dc.contributor.author | Widen, E | |
dc.contributor.author | Hottenga, JJ | |
dc.contributor.author | Kaakinen, M | |
dc.contributor.author | Lange, LA | |
dc.contributor.author | Bradfield, JP | |
dc.contributor.author | Kerkhof, M | |
dc.contributor.author | Marsh, JA | |
dc.contributor.author | Mägi, R | |
dc.contributor.author | Chen, C-M | |
dc.contributor.author | Lyon, HN | |
dc.contributor.author | Kirin, M | |
dc.contributor.author | Adair, LS | |
dc.contributor.author | Aulchenko, YS | |
dc.contributor.author | Bennett, AJ | |
dc.contributor.author | Borja, JB | |
dc.contributor.author | Bouatia-Naji, N | |
dc.contributor.author | Charoen, P | |
dc.contributor.author | Coin, LJM | |
dc.contributor.author | Cousminer, DL | |
dc.contributor.author | de Geus, EJC | |
dc.contributor.author | Deloukas, P | |
dc.contributor.author | Elliott, P | |
dc.contributor.author | Evans, DM | |
dc.contributor.author | Froguel, P | |
dc.contributor.author | Genetic Investigation of ANthropometric Traits (GIANT) Consortium | |
dc.contributor.author | Glaser, B | |
dc.contributor.author | Groves, CJ | |
dc.contributor.author | Hartikainen, A-L | |
dc.contributor.author | Hassanali, N | |
dc.contributor.author | Hirschhorn, JN | |
dc.contributor.author | Hofman, A | |
dc.contributor.author | Holly, JMP | |
dc.contributor.author | Hyppönen, E | |
dc.contributor.author | Kanoni, S | |
dc.contributor.author | Knight, BA | |
dc.contributor.author | Laitinen, J | |
dc.contributor.author | Lindgren, CM | |
dc.contributor.author | Meta-Analyses of Glucose and Insulin-related traits Consortium | |
dc.contributor.author | McArdle, WL | |
dc.contributor.author | O'Reilly, PF | |
dc.contributor.author | Pennell, CE | |
dc.contributor.author | Postma, DS | |
dc.contributor.author | Pouta, A | |
dc.contributor.author | Ramasamy, A | |
dc.contributor.author | Rayner, NW | |
dc.contributor.author | Ring, SM | |
dc.contributor.author | Rivadeneira, F | |
dc.contributor.author | Shields, BM | |
dc.contributor.author | Strachan, DP | |
dc.contributor.author | Surakka, I | |
dc.contributor.author | Taanila, A | |
dc.contributor.author | Tiesler, C | |
dc.contributor.author | Uitterlinden, AG | |
dc.contributor.author | van Duijn, CM | |
dc.contributor.author | Wellcome Trust Case Control Consortium | |
dc.contributor.author | Wijga, AH | |
dc.contributor.author | Willemsen, G | |
dc.contributor.author | Zhang, H | |
dc.contributor.author | Zhao, J | |
dc.contributor.author | Wilson, JF | |
dc.contributor.author | Steegers, EAP | |
dc.contributor.author | Hattersley, AT | |
dc.contributor.author | Eriksson, JG | |
dc.contributor.author | Peltonen, L | |
dc.contributor.author | Mohlke, KL | |
dc.contributor.author | Grant, SFA | |
dc.contributor.author | Hakonarson, H | |
dc.contributor.author | Koppelman, GH | |
dc.contributor.author | Dedoussis, GV | |
dc.contributor.author | Heinrich, J | |
dc.contributor.author | Gillman, MW | |
dc.contributor.author | Palmer, LJ | |
dc.contributor.author | Frayling, TM | |
dc.contributor.author | Boomsma, DI | |
dc.contributor.author | Davey Smith, G | |
dc.contributor.author | Power, C | |
dc.contributor.author | Jaddoe, VWV | |
dc.contributor.author | Jarvelin, M-R | |
dc.contributor.author | Early Growth Genetics (EGG) Consortium | |
dc.contributor.author | McCarthy, MI | |
dc.date.accessioned | 2017-02-27T13:45:22Z | |
dc.date.issued | 2010-05 | |
dc.description.abstract | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. | en_GB |
dc.description.sponsorship | See acknowledgments | en_GB |
dc.identifier.citation | Vol. 42, pp. 430 - 435 | en_GB |
dc.identifier.doi | 10.1038/ng.567 | |
dc.identifier.uri | http://hdl.handle.net/10871/26079 | |
dc.language.iso | en | en_GB |
dc.publisher | Nature Publishing Group | en_GB |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pubmed/20372150 | en_GB |
dc.subject | Adenylyl Cyclases | en_GB |
dc.subject | Alleles | en_GB |
dc.subject | Birth Weight | en_GB |
dc.subject | Cohort Studies | en_GB |
dc.subject | Cyclins | en_GB |
dc.subject | Diabetes Mellitus, Type 2 | en_GB |
dc.subject | Ethnic Groups | en_GB |
dc.subject | Female | en_GB |
dc.subject | Genetic Predisposition to Disease | en_GB |
dc.subject | Genotype | en_GB |
dc.subject | Glucose | en_GB |
dc.subject | Humans | en_GB |
dc.subject | Isoenzymes | en_GB |
dc.subject | Male | en_GB |
dc.subject | Models, Genetic | en_GB |
dc.subject | Pregnancy | en_GB |
dc.title | Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight | en_GB |
dc.type | Article | en_GB |
dc.date.available | 2017-02-27T13:45:22Z | |
dc.identifier.issn | 1546-1718 | |
exeter.place-of-publication | United States | en_GB |
dc.description | This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record. | en_GB |
dc.identifier.journal | Nature Genetics | en_GB |
dc.identifier.pmcid | PMC2862164 | |
dc.identifier.pmid | 20372150 | |