Altered synapse stability in the early stages of tauopathy
Jackson, J; Witton, J; Johnson, J; et al.Zeshan, A; Ward, M; Randall, A; Hutton, M; Isaac, J; O'Neill, M; Ashby, M
Date: 28 March 2017
Article
Journal
Cell Reports
Publisher
Elsevier (Cell Press)
Publisher DOI
Abstract
Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse
density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse
model of tauopathy-associated dementia. Strikingly, ...
Synapse loss is a key feature of dementia but it is unclear whether synaptic dysfunction precedes degenerative phases of the disease. Here, we show that, even before any decrease in synapse
density, there is abnormal turnover of cortical axonal boutons and dendritic spines in a mouse
model of tauopathy-associated dementia. Strikingly, tauopathy drives a mismatch in synapse
turnover; postsynaptic spines turn over more rapidly whereas presynaptic boutons are stablised.
This imbalance between pre- and post-synaptic stability coincides with reduced synaptically-
driven neuronal activity in pre-degenerative stages of the disease.
Institute of Biomedical & Clinical Science
Collections of Former Colleges
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