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Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system

dc.contributor.authorRandall, AD
dc.contributor.authorKurihara, M
dc.contributor.authorBrandon, NJ
dc.contributor.authorBrown, JT
dc.date.accessioned2017-03-13T09:06:07Z
dc.date.issued2014-04
dc.description.abstractThe disrupted in schizophrenia 1 (DISC1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system (CNS) malfunction has triggered intensive investigation of the biological roles played by DISC1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular-level analysis of the assemblies that DISC1 forms with other proteins. Here, we discuss the evidence for a role of DISC1 in synaptic function in the mammalian CNS.en_GB
dc.description.sponsorshipM. Kurihara was supported by a Medical Research Council Industrial collaborative studentship in collaboration with Pfizer, who also supported aspects of DISC1-related work in A. D. Randall’s laboratoryen_GB
dc.identifier.citationVol. 39, pp. 1068 - 1073en_GB
dc.identifier.doi10.1111/ejn.12500
dc.identifier.urihttp://hdl.handle.net/10871/26476
dc.language.isoenen_GB
dc.publisherWileyen_GB
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/24712987en_GB
dc.rights© 2014 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_GB
dc.subjectelecrtophysiologyen_GB
dc.subjectneurophysiologyen_GB
dc.subjectpsychiatric geneticsen_GB
dc.subjectsynaptic physiologyen_GB
dc.subjectsynaptic plasticityen_GB
dc.subjectAnimalsen_GB
dc.subjectCerebral Cortexen_GB
dc.subjectHippocampusen_GB
dc.subjectHumansen_GB
dc.subjectMental Disordersen_GB
dc.subjectNerve Tissue Proteinsen_GB
dc.subjectSynaptic Transmissionen_GB
dc.titleDisrupted in schizophrenia 1 and synaptic function in the mammalian central nervous systemen_GB
dc.typeArticleen_GB
dc.date.available2017-03-13T09:06:07Z
dc.identifier.issn0953-816X
exeter.place-of-publicationFranceen_GB
dc.descriptionThis is the final version of the article. Available from the publisher via the DOI in this record.en_GB
dc.identifier.journalEuropean Journal of Neuroscienceen_GB
dc.identifier.pmcidPMC4232872
dc.identifier.pmid24712987


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