Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations
Costello, J; Castro, I; Schrader, TA; et al.Islinger, M; Schrader, M
Date: 2 May 2017
Article
Journal
Cell Cycle
Publisher
Taylor & Francis
Publisher DOI
Abstract
Cooperation between cellular organelles such as mitochondria, peroxisomes and the ER is
essential for a variety of important and diverse metabolic processes. Effective communication
and metabolite exchange requires physical linkages between the organelles, predominantly in
the form of organelle contact sites. At such contact sites ...
Cooperation between cellular organelles such as mitochondria, peroxisomes and the ER is
essential for a variety of important and diverse metabolic processes. Effective communication
and metabolite exchange requires physical linkages between the organelles, predominantly in
the form of organelle contact sites. At such contact sites organelle membranes are brought
into close proximity by the action of molecular tethers, which often consist of specific protein
pairs anchored in the membrane of the opposing organelles. Currently numerous tethering
components have been identified which link the ER with multiple other organelles but
knowledge of the factors linking the ER with peroxisomes is limited. Peroxisome-ER
interplay is important because it is required for the biosynthesis of unsaturated fatty acids,
ether-phospholipids and sterols with defects in these functions leading to severe diseases.
Here we characterise acyl-CoA binding domain protein 4 (ACBD4) as a tail-anchored
peroxisomal membrane protein which interacts with the ER protein, vesicle-associated
membrane protein-associated protein–B (VAPB) to promote peroxisome-ER associations.
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